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    ZC3H7A zinc finger CCCH-type containing 7A [ Homo sapiens (human) ]

    Gene ID: 29066, updated on 27-Nov-2024

    Summary

    Official Symbol
    ZC3H7Aprovided by HGNC
    Official Full Name
    zinc finger CCCH-type containing 7Aprovided by HGNC
    Primary source
    HGNC:HGNC:30959
    See related
    Ensembl:ENSG00000122299 MIM:619819; AllianceGenome:HGNC:30959
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZC3H7; HSPC055; ZC3HDC7
    Summary
    Enables miRNA binding activity. Involved in miRNA processing. Acts upstream of with a positive effect on post-transcriptional regulation of gene expression. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 13.3), lymph node (RPKM 12.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZC3H7A in Genome Data Viewer
    Location:
    16p13.13
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (11750597..11797258, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (11786640..11833292, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (11844453..11891114, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene nonconserved acetylation island sequence 94 enhancer Neighboring gene stannin Neighboring gene thioredoxin domain containing 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10456 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:11836693-11837215 Neighboring gene TXNDC11 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10457 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10458 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10459 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7209 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:11890813-11891350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11915504-11916004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11916005-11916505 Neighboring gene breast cancer anti-estrogen resistance 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:11932294-11932479 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:11944561-11945760 Neighboring gene ribosomal L1 domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Common variants at ten loci influence QT interval duration in the QTGEN Study.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10027, FLJ20318

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables miRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables miRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in miRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_positive_effect post-transcriptional regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger CCCH domain-containing protein 7A
    Names
    zinc finger CCCH-type domain containing 7
    zinc-finger protein AY163807

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014153.4NP_054872.2  zinc finger CCCH domain-containing protein 7A

      See identical proteins and their annotated locations for NP_054872.2

      Status: VALIDATED

      Source sequence(s)
      AY163807, BC046363, DA160892
      Consensus CDS
      CCDS10550.1
      UniProtKB/Swiss-Prot
      D3DUG5, Q8IWR0, Q9NPE9
      Related
      ENSP00000347999.4, ENST00000355758.9
      Conserved Domains (5) summary
      smart00356
      Location:906926
      ZnF_C3H1; zinc finger
      sd00020
      Location:859881
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00006
      Location:4671
      TPR; TPR repeat [structural motif]
      pfam12171
      Location:857882
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      pfam13414
      Location:44119
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      11750597..11797258 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522463.3XP_011520765.1  zinc finger CCCH domain-containing protein 7A isoform X1

      See identical proteins and their annotated locations for XP_011520765.1

      UniProtKB/Swiss-Prot
      D3DUG5, Q8IWR0, Q9NPE9
      Conserved Domains (5) summary
      smart00356
      Location:906926
      ZnF_C3H1; zinc finger
      sd00020
      Location:859881
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00006
      Location:4671
      TPR; TPR repeat [structural motif]
      pfam12171
      Location:857882
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      pfam13414
      Location:44119
      TPR_11; TPR repeat
    2. XM_047433996.1XP_047289952.1  zinc finger CCCH domain-containing protein 7A isoform X1

      UniProtKB/Swiss-Prot
      D3DUG5, Q8IWR0, Q9NPE9
    3. XM_006720877.3XP_006720940.1  zinc finger CCCH domain-containing protein 7A isoform X1

      See identical proteins and their annotated locations for XP_006720940.1

      UniProtKB/Swiss-Prot
      D3DUG5, Q8IWR0, Q9NPE9
      Conserved Domains (5) summary
      smart00356
      Location:906926
      ZnF_C3H1; zinc finger
      sd00020
      Location:859881
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00006
      Location:4671
      TPR; TPR repeat [structural motif]
      pfam12171
      Location:857882
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      pfam13414
      Location:44119
      TPR_11; TPR repeat
    4. XM_017023174.2XP_016878663.1  zinc finger CCCH domain-containing protein 7A isoform X2

    5. XM_011522464.3XP_011520766.1  zinc finger CCCH domain-containing protein 7A isoform X4

      Conserved Domains (3) summary
      smart00356
      Location:667687
      ZnF_C3H1; zinc finger
      sd00020
      Location:620642
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:618643
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    6. XM_047433998.1XP_047289954.1  zinc finger CCCH domain-containing protein 7A isoform X5

    7. XM_047433997.1XP_047289953.1  zinc finger CCCH domain-containing protein 7A isoform X3

      Related
      ENSP00000459747.1, ENST00000571198.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      11786640..11833292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380153.1XP_054236128.1  zinc finger CCCH domain-containing protein 7A isoform X1

      UniProtKB/Swiss-Prot
      D3DUG5, Q8IWR0, Q9NPE9
    2. XM_054380155.1XP_054236130.1  zinc finger CCCH domain-containing protein 7A isoform X1

      UniProtKB/Swiss-Prot
      D3DUG5, Q8IWR0, Q9NPE9
    3. XM_054380154.1XP_054236129.1  zinc finger CCCH domain-containing protein 7A isoform X1

      UniProtKB/Swiss-Prot
      D3DUG5, Q8IWR0, Q9NPE9
    4. XM_054380156.1XP_054236131.1  zinc finger CCCH domain-containing protein 7A isoform X2

    5. XM_054380158.1XP_054236133.1  zinc finger CCCH domain-containing protein 7A isoform X4

    6. XM_054380159.1XP_054236134.1  zinc finger CCCH domain-containing protein 7A isoform X5

    7. XM_054380157.1XP_054236132.1  zinc finger CCCH domain-containing protein 7A isoform X3