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    TAS2R8 taste 2 receptor member 8 [ Homo sapiens (human) ]

    Gene ID: 50836, updated on 27-Nov-2024

    Summary

    Official Symbol
    TAS2R8provided by HGNC
    Official Full Name
    taste 2 receptor member 8provided by HGNC
    Primary source
    HGNC:HGNC:14915
    See related
    Ensembl:ENSG00000121314 MIM:604794; AllianceGenome:HGNC:14915
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    T2R8; TRB5
    Summary
    This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]
    Orthologs
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    Genomic context

    See TAS2R8 in Genome Data Viewer
    Location:
    12p13.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (10806051..10807286, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (10679133..10680368, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (10958650..10959885, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2366 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 12 Neighboring gene taste 2 receptor member 7 Neighboring gene taste 2 receptor member 9 Neighboring gene taste 2 receptor member 10

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    taste receptor type 2 member 8
    Names
    taste receptor, family B, member 5
    taste receptor, type 2, member 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023918.3NP_076407.1  taste receptor type 2 member 8

      See identical proteins and their annotated locations for NP_076407.1

      Status: REVIEWED

      Source sequence(s)
      AC006518
      Consensus CDS
      CCDS8632.1
      UniProtKB/Swiss-Prot
      Q4KN29, Q645Y2, Q9NYW2
      UniProtKB/TrEMBL
      Q4KN04
      Related
      ENSP00000240615.2, ENST00000240615.3
      Conserved Domains (1) summary
      cd15022
      Location:7298
      7tm_TAS2R8; mammalian taste receptor 2, subtype 8, member of the seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      10806051..10807286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003571050.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      4757..5992 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_187658.1 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      4757..5992 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      10679133..10680368 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)