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    pfkpa phosphofructokinase, platelet a [ Danio rerio (zebrafish) ]

    Gene ID: 560944, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pfkpaprovided by ZNC
    Official Full Name
    phosphofructokinase, platelet aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-091112-22
    See related
    Ensembl:ENSDARG00000028000 AllianceGenome:ZFIN:ZDB-GENE-091112-22
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch73-73n3.1
    Summary
    Predicted to enable 6-phosphofructokinase activity and fructose-6-phosphate binding activity. Predicted to be involved in canonical glycolysis; fructose 1,6-bisphosphate metabolic process; and fructose 6-phosphate metabolic process. Predicted to act upstream of or within glycolytic process and phosphorylation. Predicted to be located in cytoplasm. Predicted to be part of 6-phosphofructokinase complex. Predicted to be active in membrane. Is expressed in cardiac ventricle. Orthologous to human PFKP (phosphofructokinase, platelet). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pfkpa in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (3963804..4003405)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (3931983..3972265)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137489280 Neighboring gene uncharacterized LOC137489279 Neighboring gene Kruppel like factor 6a Neighboring gene cyclin Y

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A regeneration-triggered metabolic adaptation is necessary for cell identity transitions and cell cycle re-entry to support blastema formation and bone regeneration. Brandão AS, et al. Elife, 2022 Aug 22. PMID 35993337, Free PMC Article
    2. Foxm1 regulates cardiomyocyte proliferation in adult zebrafish after cardiac injury. Zuppo DA, et al. Development, 2023 Mar 15. PMID 36846912, Free PMC Article
    3. Stimulation of glycolysis promotes cardiomyocyte proliferation after injury in adult zebrafish. Fukuda R, et al. EMBO Rep, 2020 Aug 5. PMID 32648304, Free PMC Article
    4. High-Resolution Proteomic Profiling Shows Sexual Dimorphism in Zebrafish Heart-Associated Proteins. Niksirat H, et al. J Proteome Res, 2021 Aug 6. PMID 34185526
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 6-phosphofructokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fructose 6-phosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent 6-phosphofructokinase, platelet type

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      3963804..4003405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009297258.4 → XP_009295533.1  ATP-dependent 6-phosphofructokinase, platelet type isoform X3

      UniProtKB/TrEMBL
      A0A2R8RK99, A0A8M3AYX7, A0A8M3B6I6
      Related
      ENSDARP00000147122.1, ENSDART00000185926.1
      Conserved Domains (2) summary
      cd00764
      Location:15 → 773
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
      TIGR02478
      Location:18 → 760
      6PF1K_euk; 6-phosphofructokinase, eukaryotic type

    2. XM_009297257.4 → XP_009295532.1  ATP-dependent 6-phosphofructokinase, platelet type isoform X1

      UniProtKB/TrEMBL
      A0A8M2B9K3, A0A8M3AP28, E7FDP2
      Related
      ENSDARP00000029635.7, ENSDART00000033394.9
      Conserved Domains (2) summary
      cd00764
      Location:15 → 773
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
      TIGR02478
      Location:18 → 760
      6PF1K_euk; 6-phosphofructokinase, eukaryotic type

    3. XM_068217141.1 → XP_068073242.1  ATP-dependent 6-phosphofructokinase, platelet type isoform X5

      UniProtKB/TrEMBL
      A0A8M2B9C5

    4. XM_002666597.7 → XP_002666643.1  ATP-dependent 6-phosphofructokinase, platelet type isoform X4

      UniProtKB/TrEMBL
      A0A0R4ITA8, A0A8M1RL68, A0A8M3B6I6
      Related
      ENSDARP00000137388.2, ENSDART00000167043.3
      Conserved Domains (2) summary
      cd00764
      Location:15 → 773
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
      TIGR02478
      Location:18 → 760
      6PF1K_euk; 6-phosphofructokinase, eukaryotic type

    5. XM_002666599.7 → XP_002666645.1  ATP-dependent 6-phosphofructokinase, platelet type isoform X2

      UniProtKB/TrEMBL
      A0A8M1RMR9, A0A8M2B9C5
      Conserved Domains (2) summary
      cd00764
      Location:15 → 773
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
      TIGR02478
      Location:18 → 760
      6PF1K_euk; 6-phosphofructokinase, eukaryotic type
    Nucleotide Protein Strain
    Heading Accession and Version

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