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    atraid all-trans retinoic acid-induced differentiation factor [ Danio rerio (zebrafish) ]

    Gene ID: 553468, updated on 2-Nov-2024

    Summary

    Official Symbol
    atraidprovided by ZNC
    Official Full Name
    all-trans retinoic acid-induced differentiation factorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040724-177
    See related
    Ensembl:ENSDARG00000043388 AllianceGenome:ZFIN:ZDB-GENE-040724-177
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    apr3; APR-3; si:ch211-101l18.3
    Summary
    Predicted to be involved in several processes, including negative regulation of osteoblast proliferation; positive regulation of bone mineralization; and positive regulation of osteoblast differentiation. Predicted to act upstream of or within cell differentiation. Predicted to be located in nuclear envelope and perinuclear region of cytoplasm. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human ATRAID (all-trans retinoic acid induced differentiation factor). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See atraid in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (19512727..19516643)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (19613144..19617060)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 513a Neighboring gene sorting nexin 17 Neighboring gene eukaryotic translation initiation factor 2B, subunit 4 delta Neighboring gene transfer RNA leucine (anticodon CAG)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of osteoblast proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of bone mineralization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of osteoblast differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of osteoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear envelope ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    all-trans retinoic acid-induced differentiation factor
    Names
    apoptosis related protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044773.1NP_001038238.1  all-trans retinoic acid-induced differentiation factor precursor

      See identical proteins and their annotated locations for NP_001038238.1

      Status: VALIDATED

      Source sequence(s)
      BC133993, BX276101, EH497084
      UniProtKB/Swiss-Prot
      A3KNS9, Q502E7, Q5RID6
      Related
      ENSDARP00000063695.5, ENSDART00000063696.6
      Conserved Domains (2) summary
      sd00031
      Location:96118
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:76124
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      19512727..19516643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)