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    otud7b OTU deubiquitinase 7B [ Danio rerio (zebrafish) ]

    Gene ID: 777637, updated on 14-Nov-2024

    Summary

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    Official Symbol
    otud7bprovided by ZNC
    Official Full Name
    OTU deubiquitinase 7Bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060616-1
    See related
    Ensembl:ENSDARG00000017220 AllianceGenome:ZFIN:ZDB-GENE-060616-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    za20d1; zgc:152772
    Summary
    Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and cysteine-type deubiquitinase activity. Acts upstream of or within Notch signaling pathway. Predicted to be active in cytoplasm and nucleus. Orthologous to human OTUD7B (OTU deubiquitinase 7B). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See otud7b in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (45930940..45982662)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (45964239..46017279)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene synaptic Ras GTPase activating protein 1b Neighboring gene RNA binding motif protein 8A Neighboring gene antifreeze protein type IV Neighboring gene myotubularin related protein 11 Neighboring gene uncharacterized LOC137487856

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article
    2. Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Thyme SB, et al. Cell, 2019 Apr 4. PMID 30929901, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    OTU domain-containing protein 7B
    Names
    OTU domain containing 7B
    zinc finger, A20 domain containing 1
    NP_001071212.1
    XP_005158443.1
    XP_005158444.1
    XP_005158446.1
    XP_021322432.1
    XP_068070120.1
    XP_068070121.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077744.1 → NP_001071212.1  OTU domain-containing protein 7B

      See identical proteins and their annotated locations for NP_001071212.1

      Status: PROVISIONAL

      Source sequence(s)
      BC125816
      UniProtKB/TrEMBL
      A0JMB7
      Related
      ENSDARP00000041810.6, ENSDART00000041811.8
      Conserved Domains (3) summary
      cd14347
      Location:4 → 46
      UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
      pfam01754
      Location:878 → 902
      zf-A20; A20-like zinc finger
      cl19932
      Location:183 → 350
      OTU; OTU-like cysteine protease

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      45930940..45982662
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005158386.5 → XP_005158443.1  OTU domain-containing protein 7B isoform X1

      UniProtKB/TrEMBL
      A0A8M2B591
      Conserved Domains (3) summary
      cd14347
      Location:4 → 46
      UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
      pfam01754
      Location:881 → 905
      zf-A20; A20-like zinc finger
      cl19932
      Location:184 → 351
      OTU; OTU-like cysteine protease

    2. XM_021466757.2 → XP_021322432.1  OTU domain-containing protein 7B isoform X3

      UniProtKB/TrEMBL
      A0A8M9NZE1
      Conserved Domains (3) summary
      cd14347
      Location:4 → 46
      UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
      pfam01754
      Location:880 → 904
      zf-A20; A20-like zinc finger
      cl19932
      Location:184 → 351
      OTU; OTU-like cysteine protease

    3. XM_005158389.5 → XP_005158446.1  OTU domain-containing protein 7B isoform X4

      UniProtKB/TrEMBL
      A0A8M2B4T1
      Conserved Domains (3) summary
      cd14347
      Location:4 → 46
      UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
      pfam01754
      Location:879 → 903
      zf-A20; A20-like zinc finger
      cl19932
      Location:184 → 351
      OTU; OTU-like cysteine protease

    4. XM_068214020.1 → XP_068070121.1  OTU domain-containing protein 7B isoform X6

    5. XM_005158387.5 → XP_005158444.1  OTU domain-containing protein 7B isoform X2

      UniProtKB/TrEMBL
      A0A8M2B4S2
      Conserved Domains (3) summary
      cd14347
      Location:4 → 46
      UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
      pfam01754
      Location:880 → 904
      zf-A20; A20-like zinc finger
      cl19932
      Location:183 → 350
      OTU; OTU-like cysteine protease

    6. XM_068214019.1 → XP_068070120.1  OTU domain-containing protein 7B isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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