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    mtx1b metaxin 1b [ Danio rerio (zebrafish) ]

    Gene ID: 286740, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mtx1bprovided by ZNC
    Official Full Name
    metaxin 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-021210-1
    See related
    Ensembl:ENSDARG00000036109 AllianceGenome:ZFIN:ZDB-GENE-021210-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mtx1; zgc:101675
    Summary
    Predicted to be involved in mitochondrion organization. Predicted to act upstream of or within protein transport. Predicted to be located in mitochondrial outer membrane. Predicted to be part of SAM complex. Predicted to be active in cytoplasm. Is expressed in alar plate midbrain region; immature eye; myotome; and optic tectum. Orthologous to human MTX1 (metaxin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See mtx1b in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (24447271..24484762, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (24864369..24900535, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene si:dkey-81h8.1 Neighboring gene thrombospondin 3b Neighboring gene thioredoxin interacting protein a Neighboring gene RNA polymerase III subunit GL a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The zebrafish metaxin 3 gene (mtx3): cDNA and protein structure, and comparison to zebrafish metaxins 1 and 2. Adolph KW. Gene, 2004 Apr 14. PMID 15087125
    2. Phylogenomic analysis of vertebrate thrombospondins reveals fish-specific paralogues, ancestral gene relationships and a tetrapod innovation. McKenzie P, et al. BMC Evol Biol, 2006 Apr 18. PMID 16620379, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC101675

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SAM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SAM complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    metaxin-1b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007280.1 → NP_001007281.1  metaxin-1b

      See identical proteins and their annotated locations for NP_001007281.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085411
      UniProtKB/TrEMBL
      Q5RKQ2
      Related
      ENSDARP00000052421.2, ENSDART00000052422.3
      Conserved Domains (2) summary
      cd03212
      Location:106 → 242
      GST_C_Metaxin1_3; C-terminal, alpha helical domain of Metaxin 1, Metaxin 3, and similar proteins
      cd03078
      Location:5 → 78
      GST_N_Metaxin1_like; GST_N family, Metaxin subfamily, Metaxin 1-like proteins; composed of metaxins 1 and 3, and similar proteins including Tom37 from fungi. Mammalian metaxin (or metaxin 1) and the fungal protein Tom37 are components of preprotein import complexes of the ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      24447271..24484762 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021467980.2 → XP_021323655.1  metaxin-1b isoform X1

      UniProtKB/TrEMBL
      A0A8M9PR98
      Conserved Domains (2) summary
      cd03212
      Location:106 → 242
      GST_C_Metaxin1_3; C-terminal, alpha helical domain of Metaxin 1, Metaxin 3, and similar proteins
      pfam10568
      Location:7 → 144
      Tom37; Outer mitochondrial membrane transport complex protein
    Nucleotide Protein
    Heading Accession and Version

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