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    tsc1a TSC complex subunit 1a [ Danio rerio (zebrafish) ]

    Gene ID: 337167, updated on 2-Nov-2024

    Summary

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    Official Symbol
    tsc1aprovided by ZNC
    Official Full Name
    TSC complex subunit 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9111
    See related
    Ensembl:ENSDARG00000026048 AllianceGenome:ZFIN:ZDB-GENE-030131-9111
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa99f04; zgc:63657; wu:fa99f04
    Summary
    Acts upstream of or within several processes, including cilium assembly; determination of left/right symmetry; and regulation of TOR signaling. Located in Golgi apparatus. Is expressed in notochord; polster; pronephric duct; and somite. Human ortholog(s) of this gene implicated in intellectual disability; lymphangioleiomyomatosis; tuberous sclerosis; and tuberous sclerosis 1. Orthologous to human TSC1 (TSC complex subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tsc1a in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (29652468..29668982)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (29052295..29068818)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene ectonucleoside triphosphate diphosphohydrolase 2a, tandem duplicate 1 Neighboring gene glutamate receptor, ionotropic, N-methyl D-aspartate 1b Neighboring gene sperm acrosome associated 9 Neighboring gene adenylate kinase 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Target-of-rapamycin complex 1 (Torc1) signaling modulates cilia size and function through protein synthesis regulation. Yuan S, et al. Proc Natl Acad Sci U S A, 2012 Feb 7. PMID 22308353, Free PMC Article
    2. Zebrafish Tsc1 reveals functional interactions between the cilium and the TOR pathway. DiBella LM, et al. Hum Mol Genet, 2009 Feb 15. PMID 19008302, Free PMC Article
    3. Zebrafish tsc1 and cxcl12a increase susceptibility to mycobacterial infection. Wright K, et al. Life Sci Alliance, 2024 Apr. PMID 38307625, Free PMC Article
    4. Maternal exposure to the water soluble fraction of crude oil, lead and their mixture induces autism-like behavioral deficits in zebrafish (Danio rerio) larvae. Wang Y, et al. Ecotoxicol Environ Saf, 2016 Dec. PMID 27573365
    5. Rapamycin reduces mortality in acute-stage paraquat-induced toxicity in zebrafish. Feng N, et al. Singapore Med J, 2019 May. PMID 30402654, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within pronephros development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within pronephros development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of TSC1-TSC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TSC complex subunit 1a
    Names
    tuberous sclerosis 1a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200052.1 → NP_956346.1  TSC complex subunit 1a

      See identical proteins and their annotated locations for NP_956346.1

      Status: PROVISIONAL

      Source sequence(s)
      BC055190
      UniProtKB/TrEMBL
      Q7SXZ2
      Related
      ENSDARP00000035073.5, ENSDART00000035400.6
      Conserved Domains (2) summary
      pfam04388
      Location:8 → 691
      Hamartin; Hamartin protein
      pfam10211
      Location:848 → 934
      Ax_dynein_light; Axonemal dynein light chain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      29652468..29668982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005171795.5 → XP_005171852.1  TSC complex subunit 1a isoform X1

      See identical proteins and their annotated locations for XP_005171852.1

      UniProtKB/TrEMBL
      A0A2R8QHE1, A0A8M2BJK9
      Related
      ENSDARP00000153412.1, ENSDART00000184083.1
      Conserved Domains (2) summary
      pfam04388
      Location:8 → 700
      Hamartin; Hamartin protein
      pfam10211
      Location:857 → 943
      Ax_dynein_light; Axonemal dynein light chain

    2. XM_005171797.5 → XP_005171854.1  TSC complex subunit 1a isoform X2

      UniProtKB/TrEMBL
      A0A8M2BJ51
      Conserved Domains (2) summary
      pfam04388
      Location:8 → 674
      Hamartin; Hamartin protein
      pfam10211
      Location:831 → 917
      Ax_dynein_light; Axonemal dynein light chain

    3. XM_005171796.5 → XP_005171853.1  TSC complex subunit 1a isoform X1

      See identical proteins and their annotated locations for XP_005171853.1

      UniProtKB/TrEMBL
      A0A2R8QHE1, A0A8M2BJK9
      Conserved Domains (2) summary
      pfam04388
      Location:8 → 700
      Hamartin; Hamartin protein
      pfam10211
      Location:857 → 943
      Ax_dynein_light; Axonemal dynein light chain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394581.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      12064..27018
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395239.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      12053..26960
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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