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    rhocb ras homolog family member Cb [ Danio rerio (zebrafish) ]

    Gene ID: 436718, updated on 14-Nov-2024

    Summary

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    Official Symbol
    rhocbprovided by ZNC
    Official Full Name
    ras homolog family member Cbprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-144
    See related
    Ensembl:ENSDARG00000018328 AllianceGenome:ZFIN:ZDB-GENE-040718-144
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    rhoad; zgc:92350
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including actin filament organization; skeletal muscle satellite cell migration; and wound healing, spreading of cells. Predicted to act upstream of or within small GTPase-mediated signal transduction. Predicted to be located in membrane. Predicted to be active in cytosol and plasma membrane. Is expressed in dorsal aorta; intersegmental vessel; neural tube; and posterior cardinal vein. Orthologous to human RHOC (ras homolog family member C). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rhocb in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (27555372..27624329)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (27536233..27605190)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene TAFA chemokine like family member 3b Neighboring gene uncharacterized LOC101886754 Neighboring gene protein Hook homolog 1-like Neighboring gene uncharacterized LOC137496299 Neighboring gene uncharacterized LOC110440015 Neighboring gene Mov10 RNA helicase b, tandem duplicate 2 Neighboring gene Mov10 RNA helicase b, tandem duplicate 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RhoC maintains vascular homeostasis by regulating VEGF-induced signaling in endothelial cells. Hoeppner LH, et al. J Cell Sci, 2015 Oct 1. PMID 26136364, Free PMC Article
    2. Discovering miRNA Regulatory Networks in Holt-Oram Syndrome Using a Zebrafish Model. D'Aurizio R, et al. Front Bioeng Biotechnol, 2016. PMID 27471727, Free PMC Article
    3. Genomic annotation and expression analysis of the zebrafish Rho small GTPase family during development and bacterial infection. Salas-Vidal E, et al. Genomics, 2005 Jul. PMID 15894457
    4. Evolutionary and Expression Analysis of MOV10 and MOV10L1 Reveals Their Origin, Duplication and Divergence. Yang S, et al. Int J Mol Sci, 2022 Jul 7. PMID 35886872, Free PMC Article
    5. An evolutionary approach to recover genes predominantly expressed in the testes of the zebrafish, chicken and mouse. Fouchécourt S, et al. BMC Evol Biol, 2019 Jul 3. PMID 31269894, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in skeletal muscle satellite cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in wound healing, spreading of cells ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho-related GTP-binding protein RhoA-D
    Names
    ras homolog gene family, member Ad
    rho-related GTP-binding protein RhoC
    NP_001002445.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002445.1 → NP_001002445.1  rho-related GTP-binding protein RhoA-D

      See identical proteins and their annotated locations for NP_001002445.1

      Status: PROVISIONAL

      Source sequence(s)
      BC076026
      UniProtKB/Swiss-Prot
      Q6DHE8
      Related
      ENSDARP00000002761.7, ENSDART00000016696.8
      Conserved Domains (2) summary
      smart00174
      Location:8 → 180
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cd01870
      Location:5 → 179
      RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      27555372..27624329
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394727.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      552139..593364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DHE8.1 GenPept UniProtKB/Swiss-Prot:Q6DHE8

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