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    pygmb phosphorylase, glycogen, muscle b [ Danio rerio (zebrafish) ]

    Gene ID: 393444, updated on 2-Nov-2024

    Summary

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    Official Symbol
    pygmbprovided by ZNC
    Official Full Name
    phosphorylase, glycogen, muscle bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1206
    See related
    Ensembl:ENSDARG00000013317 AllianceGenome:ZFIN:ZDB-GENE-040426-1206
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:63642
    Summary
    Predicted to enable glycogen phosphorylase activity and pyridoxal phosphate binding activity. Acts upstream of or within carbohydrate storage and skeletal muscle fiber development. Predicted to be active in cytoplasm. Is expressed in several structures, including eye; heart; immune system; integument; and muscle. Human ortholog(s) of this gene implicated in glycogen storage disease V. Orthologous to human PYGM (glycogen phosphorylase, muscle associated). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See pygmb in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (22823889..22852174)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (22552732..22581017)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 4.1 Neighboring gene splicing factor 1 Neighboring gene chloride channel, voltage-sensitive 5b Neighboring gene TNF superfamily member 10, like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The effect of muscle glycogen phosphorylase (Pygm) knockdown on zebrafish morphology. Migocka-Patrzałek M, et al. Int J Biochem Cell Biol, 2020 Jan. PMID 31747538
    2. Bisphenol S exposure impairs glucose homeostasis in male zebrafish (Danio rerio). Zhao F, et al. Ecotoxicol Environ Saf, 2018 Jan. PMID 28946120
    3. Ghrelin affects carbohydrate-glycogen metabolism via insulin inhibition and glucagon stimulation in the zebrafish (Danio rerio) brain. Cruz SA, et al. Comp Biochem Physiol A Mol Integr Physiol, 2010 Jun. PMID 20138234
    4. The dysfunction of hormone-sensitive lipase induces lipid deposition and reprogramming of nutrient metabolism in fish. Wang JG, et al. Br J Nutr, 2023 Aug 28. PMID 36408747
    5. Different physiological roles of insulin receptors in mediating nutrient metabolism in zebrafish. Yang BY, et al. Am J Physiol Endocrinol Metab, 2018 Jul 1. PMID 29351486

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The effect of muscle glycogen phosphorylase (Pygm) knockdown on zebrafish morphology.
      Title: The effect of muscle glycogen phosphorylase (Pygm) knockdown on zebrafish morphology.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC63642

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 1,4-alpha-oligoglucan phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycogen phosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycogen phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within carbohydrate storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycogen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glycogen metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within skeletal muscle fiber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphorylase, glycogen, muscle b
    NP_001314960.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328031.1 → NP_001314960.1  phosphorylase, glycogen, muscle b

      Status: PROVISIONAL

      Source sequence(s)
      AL928799
      UniProtKB/TrEMBL
      A0A8M1P9E8, E7EXT3
      Related
      ENSDARP00000111947.1, ENSDART00000127467.4
      Conserved Domains (2) summary
      cd04300
      Location:29 → 827
      GT1_Glycogen_Phosphorylase; This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of ...
      TIGR02093
      Location:32 → 827
      P_ylase; glycogen/starch/alpha-glucan phosphorylases

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      22823889..22852174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_200472.1: Suppressed sequence

      Description
      NM_200472.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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