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    nnt nicotinamide nucleotide transhydrogenase [ Danio rerio (zebrafish) ]

    Gene ID: 406619, updated on 2-Nov-2024

    Summary

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    Official Symbol
    nntprovided by ZNC
    Official Full Name
    nicotinamide nucleotide transhydrogenaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2592
    See related
    Ensembl:ENSDARG00000023536 AllianceGenome:ZFIN:ZDB-GENE-040426-2592
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:76979; wu:fa20d10; wu:fc86a04
    Summary
    Predicted to enable NADP binding activity. Acts upstream of or within regulation of pigmentation. Predicted to be located in membrane. Is expressed in female organism. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Orthologous to human NNT (nicotinamide nucleotide transhydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See nnt in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (19763546..19828386, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (19726910..19791750, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene retinoic acid induced 14 Neighboring gene si:ch211-262i10.2 Neighboring gene fibroblast growth factor 10a Neighboring gene coiled-coil domain containing 80 like 2 Neighboring gene FYN binding protein 1 b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Loss of Nicotinamide nucleotide transhydrogenase sensitizes embryos to ethanol-induced neural crest and neural apoptosis via generation of reactive oxygen species. Mazumdar R, et al. Front Neurosci, 2023. PMID 37360166, Free PMC Article
    2. MITF regulates IDH1, NNT, and a transcriptional program protecting melanoma from reactive oxygen species. Roider E, et al. Sci Rep, 2024 Sep 14. PMID 39277608, Free PMC Article
    3. NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism. Allouche J, et al. Cell, 2021 Aug 5. PMID 34233163, Free PMC Article
    4. Loss of Function Mutations in NNT Are Associated With Left Ventricular Noncompaction. Bainbridge MN, et al. Circ Cardiovasc Genet, 2015 Aug. PMID 26025024, Free PMC Article
    5. Spatiotemporal expression and transcriptional regulation of heme oxygenase and biliverdin reductase genes in zebrafish (Danio rerio) suggest novel roles during early developmental periods of heightened oxidative stress. Holowiecki A, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2017 Jan. PMID 27760386, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MITF regulates IDH1, NNT, and a transcriptional program protecting melanoma from reactive oxygen species.
      Title: MITF regulates IDH1, NNT, and a transcriptional program protecting melanoma from reactive oxygen species.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables NADP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proton-translocating NAD(P)+ transhydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADPH regeneration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NAD(P) transhydrogenase, mitochondrial
    NP_999921.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214756.1 → NP_999921.1  NAD(P) transhydrogenase, mitochondrial

      See identical proteins and their annotated locations for NP_999921.1

      Status: PROVISIONAL

      Source sequence(s)
      BC066499
      UniProtKB/TrEMBL
      A9JRP9, Q6NYQ7
      Related
      ENSDARP00000032730.6, ENSDART00000037664.8
      Conserved Domains (4) summary
      PRK09424
      Location:53 → 583
      pntA; NAD(P) transhydrogenase subunit alpha; Provisional
      cd05304
      Location:53 → 428
      Rubrum_tdh; Rubrum transdehydrogenase NAD-binding and catalytic domains
      pfam02233
      Location:618 → 1072
      PNTB; NAD(P) transhydrogenase beta subunit
      pfam12769
      Location:498 → 583
      PNTB_4TM; 4TM region of pyridine nucleotide transhydrogenase, mitoch

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      19763546..19828386 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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