scarb2a scavenger receptor class B, member 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: scarb2aprovided by ZNC
Official Full Name: scavenger receptor class B, member 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020419-29
See related: Ensembl:ENSDARG00000098312 AllianceGenome:ZFIN:ZDB-GENE-020419-29
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cd36l2; scarb2; fi13c07; chunp6914; wu:fi13c07
Summary: Predicted to enable scavenger receptor activity. Acts upstream of or within notochord development. Predicted to be located in lysosome and membrane. Predicted to be active in lysosomal membrane and plasma membrane. Is expressed in several structures, including alar plate midbrain region; axial mesoderm; hindbrain neural plate; nervous system; and notochord. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 4. Orthologous to human SCARB2 (scavenger receptor class B member 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (52845268..52860140)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (52198675..52213547)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This work describes a novel function for the Scarb2 receptor as an essential glycoprotein for notochord development.
Title: Zebrafish scarb2a insertional mutant reveals a novel function for the Scarb2/Limp2 receptor in notochord development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables scavenger receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables scavenger receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within notochord development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to lysosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor-mediated endocytosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: lysosome membrane protein 2a

Names: CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2; CD36 antigen-like 2; scavenger receptor class B, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.