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    pik3r3b phosphoinositide-3-kinase, regulatory subunit 3b (gamma) [ Danio rerio (zebrafish) ]

    Gene ID: 100000252, updated on 14-Nov-2024

    Summary

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    Official Symbol
    pik3r3bprovided by ZNC
    Official Full Name
    phosphoinositide-3-kinase, regulatory subunit 3b (gamma)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-743
    See related
    Ensembl:ENSDARG00000034409 AllianceGenome:ZFIN:ZDB-GENE-040426-743
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pik3r3; zgc:55564; zgc:85710
    Summary
    Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in insulin receptor signaling pathway. Predicted to act upstream of or within phosphorylation and signal transduction. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA. Is expressed in several structures, including immature eye; nervous system; neural tube; periderm; and skeletal muscle. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pik3r3b in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (33245851..33558977)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (33261168..33574287)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) Neighboring gene tetraspanin 1 Neighboring gene uncharacterized LOC137495980 Neighboring gene microtubule associated serine/threonine kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Aryl hydrocarbon receptor activation produces heart-specific transcriptional and toxic responses in developing zebrafish. Carney SA, et al. Mol Pharmacol, 2006 Aug. PMID 16714409
    2. Novel zebrafish caspase-3 substrates. Valencia CA, et al. Biochem Biophys Res Commun, 2007 Sep 21. PMID 17643392
    3. Exercise intervention mitigates zebrafish age-related sarcopenia via alleviating mitochondrial dysfunction. Sun CC, et al. FEBS J, 2023 Mar. PMID 36164851
    4. Identification of Potentially Related Genes and Mechanisms Involved in Skeletal Muscle Atrophy Induced by Excessive Exercise in Zebrafish. Sun CC, et al. Biology (Basel), 2021 Aug 10. PMID 34439993, Free PMC Article
    5. The TATA-binding protein regulates maternal mRNA degradation and differential zygotic transcription in zebrafish. Ferg M, et al. EMBO J, 2007 Sep 5. PMID 17703193, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55564, MGC85710, MGC173784, MGC174729

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphoinositide-3-kinase, regulatory subunit 3b (gamma)
    Names
    phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201143.2 → NP_957437.2  phosphoinositide-3-kinase, regulatory subunit 3b (gamma)

      See identical proteins and their annotated locations for NP_957437.2

      Status: PROVISIONAL

      Source sequence(s)
      BC081552
      UniProtKB/TrEMBL
      Q66I41
      Related
      ENSDARP00000040333.5, ENSDART00000040334.6
      Conserved Domains (4) summary
      cd09930
      Location:353 → 456
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:61 → 169
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cd12925
      Location:174 → 334
      iSH2_PIK3R3; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 3, PIK3R3, also called p55gamma
      pfam16454
      Location:173 → 332
      PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      33245851..33558977
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476737.2 → XP_021332412.2  phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1

    2. XM_005166277.5 → XP_005166334.1  phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X2

      UniProtKB/TrEMBL
      A0A8M2BDR6
      Conserved Domains (4) summary
      cd09930
      Location:327 → 430
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:35 → 143
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      pfam16454
      Location:147 → 306
      PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
      cl23765
      Location:148 → 308
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394654.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      52280..74015
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395258.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      107698..281252
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021474103.2 → XP_021329778.1  phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X3

      UniProtKB/TrEMBL
      A0A8M9PRX4
      Conserved Domains (2) summary
      cl02570
      Location:116 → 307
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl17036
      Location:7 → 77
      SH3; Src Homology 3 domain superfamily

    Reference GRCz11 ALT_DRER_TU_3

    Genomic

    1. NW_018395380.1 Reference GRCz11 ALT_DRER_TU_3

      Range
      236018..257685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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