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    fbxl5 F-box and leucine-rich repeat protein 5 [ Danio rerio (zebrafish) ]

    Gene ID: 322181, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fbxl5provided by ZNC
    Official Full Name
    F-box and leucine-rich repeat protein 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-900
    See related
    Ensembl:ENSDARG00000043046 AllianceGenome:ZFIN:ZDB-GENE-030131-900
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb52d06
    Summary
    Predicted to enable iron ion binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; intracellular iron ion homeostasis; and protein ubiquitination. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBXL5 (F-box and leucine rich repeat protein 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See fbxl5 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (45868966..45885775)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (46024175..46040984)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene lamin L3 Neighboring gene synapse associated protein 1 Neighboring gene finTRIM family, member 92 Neighboring gene ATP-binding cassette, sub-family G (WHITE), member 2a Neighboring gene mucolipin TRP cation channel 3b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables iron ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within intracellular iron ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular iron ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    F-box/LRR-repeat protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301328.1 → NP_001288257.1  F-box/LRR-repeat protein 5

      Status: VALIDATED

      Source sequence(s)
      CU984603
      UniProtKB/Swiss-Prot
      Q2YDQ5
      UniProtKB/TrEMBL
      A0A8M1P6F6, F1QLP2
      Related
      ENSDARP00000106526.2, ENSDART00000123100.3
      Conserved Domains (4) summary
      cd09293
      Location:566 → 644
      AMN1; Antagonist of mitotic exit network protein 1
      cd12109
      Location:7 → 155
      Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
      sd00034
      Location:588 → 615
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:208 → 252
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      45868966..45885775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2YDQ5.2 GenPept UniProtKB/Swiss-Prot:Q2YDQ5

    Gene LinkOut

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