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    eif4g2b eukaryotic translation initiation factor 4, gamma 2b [ Danio rerio (zebrafish) ]

    Gene ID: 334618, updated on 14-Nov-2024

    Summary

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    Official Symbol
    eif4g2bprovided by ZNC
    Official Full Name
    eukaryotic translation initiation factor 4, gamma 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6550
    See related
    Ensembl:ENSDARG00000057167 AllianceGenome:ZFIN:ZDB-GENE-030131-6550
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    NAT1B; eif4g2; fb44h01; hm:zeh1307; wu:fa14h01; wu:fb44h01; wu:fb59c06; wu:fc21b05
    Summary
    Predicted to enable mRNA binding activity and translation initiation factor activity. Acts upstream of or within mesoderm development. Predicted to be part of eukaryotic translation initiation factor 4F complex. Orthologous to human EIF4G2 (eukaryotic translation initiation factor 4 gamma 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See eif4g2b in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (16715826..16726206)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (16726760..16737140)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene mgat4 family member C Neighboring gene epidermal growth factor receptor pathway substrate 8b Neighboring gene uncharacterized LOC137488266 Neighboring gene small nucleolar RNA SNORD97 Neighboring gene trichohyalin Neighboring gene lymphatic vessel endothelial hyaluronic receptor 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The eIF4G-homolog p97 can activate translation independent of caspase cleavage. Nousch M, et al. RNA, 2007 Mar. PMID 17237356, Free PMC Article
    2. Evolutionarily conserved non-AUG translation initiation in NAT1/p97/DAP5 (EIF4G2). Takahashi K, et al. Genomics, 2005 Mar. PMID 15718103
    3. Anti-apoptotic effects of IGF-I on mortality and dysmorphogenesis in tbx5-deficient zebrafish embryos. Tsai TC, et al. BMC Dev Biol, 2018 Mar 5. PMID 29506474, Free PMC Article
    4. Transcriptomic profiling of mTOR and ryanodine receptor signaling molecules in developing zebrafish in the absence and presence of PCB 95. Frank DF, et al. PeerJ, 2017. PMID 29201571, Free PMC Article
    5. A comparative map of the zebrafish genome. Woods IG, et al. Genome Res, 2000 Dec. PMID 11116086, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mesoderm development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4 gamma 2b
    Names
    eukaryotic translation initiation factor 4 gamma, 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013443.2 → NP_001013461.2  eukaryotic translation initiation factor 4 gamma 2b

      Status: VALIDATED

      Source sequence(s)
      BC109409, EB934789
      UniProtKB/TrEMBL
      A0A8M1N4J3
      Related
      ENSDARP00000074210.5, ENSDART00000079758.7
      Conserved Domains (3) summary
      cd11559
      Location:732 → 867
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      smart00544
      Location:536 → 649
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
      pfam02854
      Location:73 → 303
      MIF4G; MIF4G domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      16715826..16726206
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395017.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      421042..431445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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