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    rac1a Rac family small GTPase 1a [ Danio rerio (zebrafish) ]

    Gene ID: 327204, updated on 10-Nov-2024

    Summary

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    Official Symbol
    rac1aprovided by ZNC
    Official Full Name
    Rac family small GTPase 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5415
    See related
    Ensembl:ENSDARG00000074849 AllianceGenome:ZFIN:ZDB-GENE-030131-5415
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    rac1; zgc:55823; zgc:55917; zgc:86934; wu:fd16e02
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Acts upstream of or within cell migration involved in gastrulation; myoblast fusion; and neutrophil chemotaxis. Predicted to be active in several cellular components, including cytoplasmic vesicle; cytoskeleton; and dendritic spine. Is expressed in liver; retina; and retinal ganglion cell layer. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 48; colorectal cancer (multiple); lung cancer; and pancreatic adenocarcinoma. Orthologous to human RAC1 (Rac family small GTPase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

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    See rac1a in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (10464897..10476337, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (10427054..10438494, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene SNU13 homolog, small nuclear ribonucleoprotein b (U4/U6.U5) Neighboring gene crystallin, mu Neighboring gene Sad1 and UNC84 domain containing 1a Neighboring gene myoferlin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Elmo1 function, linked to Rac1 activity, regulates peripheral neuronal numbers and myelination in zebrafish. Mikdache A, et al. Cell Mol Life Sci, 2020 Jan. PMID 31161284, Free PMC Article
    2. Bulk Actin Dynamics Drive Phase Segregation in Zebrafish Oocytes. Shamipour S, et al. Cell, 2019 May 30. PMID 31080065
    3. RAC1 Missense Mutations in Developmental Disorders with Diverse Phenotypes. Reijnders MRF, et al. Am J Hum Genet, 2017 Sep 7. PMID 28886345, Free PMC Article
    4. Ptenb mediates gastrulation cell movements via Cdc42/AKT1 in zebrafish. Yeh CM, et al. PLoS One, 2011 Apr 11. PMID 21494560, Free PMC Article
    5. Long-Range Optogenetic Control of Axon Guidance Overcomes Developmental Boundaries and Defects. Harris JM, et al. Dev Cell, 2020 Jun 8. PMID 32516597, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Early Elmo1 and Rac1 functions are required within Schwann cells to drive radial sorting and myelination.
      Title: Elmo1 function, linked to Rac1 activity, regulates peripheral neuronal numbers and myelination in zebrafish.
    2. our data have demonstrated a causal link between excessive Rac1 activity and podocyte injury in a dosage-dependent manner
      Title: Dosage-dependent role of Rac1 in podocyte injury.
    3. Knockdown of fat1 in zebrafish causes pronephric cysts, which is partially rescued by RAC1/CDC42 activators, confirming a role of the two small GTPases in the pathogenesis.
      Title: FAT1 mutations cause a glomerulotubular nephropathy.
    4. ELMO-DOCK1, a bipartite guanine nucleotide exchange factor complex for the small GTPase Rac1, and for the membrane-cytoskeletal linker Ezrin, regulates centriole/basal body migration, docking and spacing.
      Title: The Rac1 regulator ELMO controls basal body migration and docking in multiciliated cells through interaction with Ezrin.
    5. Our data suggest that Rac contributes to the progression of melanoma and that Tiam1 may activate Rac in nodular presentations.
      Title: Constitutive RAC activation is not sufficient to initiate melanocyte neoplasia but accelerates malignant progression.
    6. Cdc42 GTPase and Rac1 GTPase act downstream of p120 catenin and require GTP exchange during gastrulation of zebrafish mesoderm.
      Title: Cdc42 GTPase and Rac1 GTPase act downstream of p120 catenin and require GTP exchange during gastrulation of zebrafish mesoderm.
    7. Reducing Rac1 activity in endodermal cells caused them to bypass the random migration phase.
      Title: Nodal signaling regulates endodermal cell motility and actin dynamics via Rac1 and Prex1.
    8. Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein.
      Title: Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55823

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rac protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell migration involved in gastrulation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell projection assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cortical cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in motor neuron axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within myoblast fusion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neutrophil chemotaxis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of neutrophil migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras-related C3 botulinum toxin substrate 1
    Names
    RAS-related C3 botulinum substrate 1
    ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
    ras-related C3 botulinum toxin substrate 1a (rho family, small GTP binding protein Rac1)
    NP_956065.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199771.1 → NP_956065.1  ras-related C3 botulinum toxin substrate 1

      See identical proteins and their annotated locations for NP_956065.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044538
      UniProtKB/TrEMBL
      F6PDM1, Q49P05, Q7ZSZ9
      Related
      ENSDARP00000096950.4, ENSDART00000106172.5
      Conserved Domains (2) summary
      smart00174
      Location:6 → 179
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cd01871
      Location:3 → 176
      Rac1_like; Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      10464897..10476337 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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