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    mbpa myelin basic protein a [ Danio rerio (zebrafish) ]

    Gene ID: 326281, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mbpaprovided by ZNC
    Official Full Name
    myelin basic protein aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030128-2
    See related
    Ensembl:ENSDARG00000036186 AllianceGenome:ZFIN:ZDB-GENE-030128-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mbp; cb274; fj33b11; wu:fj33b11; wu:fq15b02; zgc:136630
    Summary
    Predicted to be a structural constituent of myelin sheath. Located in myelin sheath and plasma membrane. Is expressed in several structures, including EVL; male organism; nervous system; otic vesicle; and periderm. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human MBP (myelin basic protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mbpa in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (21814626..21832487, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (22229724..22248302, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488507 Neighboring gene zinc finger protein 516 Neighboring gene uncharacterized LOC137488508 Neighboring gene galanin receptor 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. In vivo identification of small molecules mediating Gpr126/Adgrg6 signaling during Schwann cell development. Bradley EC, et al. Ann N Y Acad Sci, 2019 Nov. PMID 31529518, Free PMC Article
    2. Visualization of myelination in GFP-transgenic zebrafish. Jung SH, et al. Dev Dyn, 2010 Feb. PMID 19918882
    3. A novel model of demyelination and remyelination in a GFP-transgenic zebrafish. Fang Y, et al. Biol Open, 2014 Dec 19. PMID 25527642, Free PMC Article
    4. Cre-inducible site-specific recombination in zebrafish oligodendrocytes. Pinzon-Olejua A, et al. Dev Dyn, 2017 Jan. PMID 27666728
    5. Drug reprofiling using zebrafish identifies novel compounds with potential pro-myelination effects. Buckley CE, et al. Neuropharmacology, 2010 Sep. PMID 20450924

    See all (251) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dynein/dynactin is necessary for anterograde transport of Mbp mRNA in oligodendrocytes.
      Title: Dynein/dynactin is necessary for anterograde transport of Mbp mRNA in oligodendrocytes and for myelination in vivo.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC136630

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables structural constituent of myelin sheath IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in myelin sheath IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myelin basic protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      21814626..21832487 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002665557.5 → XP_002665603.1  myelin basic protein isoform X2

      UniProtKB/TrEMBL
      A0A8M1RKW5, A0A8M9P2C7, F8W3M5
      Related
      ENSDARP00000124357.2, ENSDART00000149259.4
      Conserved Domains (1) summary
      pfam01669
      Location:1 → 120
      Myelin_MBP; Myelin basic protein

    2. XM_001340280.5 → XP_001340316.2  myelin basic protein isoform X1

      UniProtKB/TrEMBL
      A0A8M1PZE1, A0A8M9P2C7, I3ITP3
      Related
      ENSDARP00000126314.1, ENSDART00000151442.3
      Conserved Domains (1) summary
      pfam01669
      Location:1 → 132
      Myelin_MBP; Myelin basic protein

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001020483.1: Suppressed sequence

      Description
      NM_001020483.1: This RefSeq was temporarily suppressed because the CDS was partial when compared to available protein (homology) data.
    Nucleotide Protein
    Heading Accession and Version

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