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    mif macrophage migration inhibitory factor [ Danio rerio (zebrafish) ]

    Gene ID: 751093, updated on 9-Dec-2024

    Summary

    Official Symbol
    mifprovided by ZNC
    Official Full Name
    macrophage migration inhibitory factorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080708-1
    See related
    Ensembl:ENSDARG00000071336 AllianceGenome:ZFIN:ZDB-GENE-080708-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable cytokine activity and phenylpyruvate tautomerase activity. Acts upstream of or within several processes, including auditory receptor cell development; embryonic morphogenesis; and negative regulation of apoptotic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; immature eye; nervous system; pectoral fin bud; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in allergic disease; asthma; cystic fibrosis; lung disease (multiple); and obesity. Orthologous to human MIF (macrophage migration inhibitory factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See mif in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (48964678..48970210)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (49976921..49982453)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene si:dkeyp-121d2.7 Neighboring gene short coiled-coil protein b Neighboring gene cleavage factor polyribonucleotide kinase subunit 1 Neighboring gene zinc finger DHHC-type palmitoyltransferase 5b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables dopachrome isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phenylpyruvate tautomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phenylpyruvate tautomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    macrophage migration inhibitory factor
    NP_001036786.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001043321.1NP_001036786.1  macrophage migration inhibitory factor

      See identical proteins and their annotated locations for NP_001036786.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ639953
      UniProtKB/TrEMBL
      A0A0R4IJM0, F6PCE0, Q0ZBR7
      Related
      ENSDARP00000096200.3, ENSDART00000105427.4
      Conserved Domains (1) summary
      cl00235
      Location:2115
      4Oxalocrotonate_Tautomerase; 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      48964678..48970210
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)