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    clcn4 chloride channel, voltage-sensitive 4 [ Danio rerio (zebrafish) ]

    Gene ID: 768175, updated on 2-Nov-2024

    Summary

    Official Symbol
    clcn4provided by ZNC
    Official Full Name
    chloride channel, voltage-sensitive 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061013-353
    See related
    Ensembl:ENSDARG00000035808 AllianceGenome:ZFIN:ZDB-GENE-061013-353
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:153764
    Summary
    Predicted to enable voltage-gated chloride channel activity. Predicted to act upstream of or within chloride transport and transmembrane transport. Predicted to be located in endosome membrane. Predicted to be active in Golgi apparatus; cytoplasmic vesicle; and plasma membrane. Is expressed in brain; eye; gill; heart; and immune system. Human ortholog(s) of this gene implicated in Raynaud-Claes syndrome. Orthologous to human CLCN4 (chloride voltage-gated channel 4). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See clcn4 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (44144611..44163164, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (43841952..43860928, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene CLIP-associating protein 1-B Neighboring gene TRAF3 interacting protein 2b Neighboring gene U4atac minor spliceosomal RNA Neighboring gene putative claudin-24 Neighboring gene uncharacterized LOC137496741 Neighboring gene claudin-34-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables voltage-gated chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables voltage-gated chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within chloride transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    H(+)/Cl(-) exchange transporter 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077318.1NP_001070786.1  H(+)/Cl(-) exchange transporter 4

      See identical proteins and their annotated locations for NP_001070786.1

      Status: PROVISIONAL

      Source sequence(s)
      BC124729
      UniProtKB/TrEMBL
      Q08BG8
      Related
      ENSDARP00000047125.6, ENSDART00000047126.7
      Conserved Domains (4) summary
      COG0517
      Location:606751
      CBS; CBS domain [Signal transduction mechanisms]
      cd03684
      Location:87593
      ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...
      cd04591
      Location:615753
      CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
      pfam00654
      Location:171573
      Voltage_CLC; Voltage gated chloride channel

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      44144611..44163164 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)