nog1 noggin 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nog1provided by ZNC
Official Full Name: noggin 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-991206-8
See related: Ensembl:ENSDARG00000058819 AllianceGenome:ZFIN:ZDB-GENE-991206-8
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zNog1; fc23h06; wu:fc23h06
Summary: Acts upstream of or within dorsal/ventral pattern formation; negative regulation of BMP signaling pathway; and negative regulation of endodermal cell fate specification. Located in Golgi apparatus and synapse. Is expressed in several structures, including central nervous system; mesoderm; neural tube; optic vesicle; and presumptive shield. Human ortholog(s) of this gene implicated in Huntington's disease; bone disease (multiple); cleft lip; and hyperopia. Orthologous to human NOG (noggin). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (10310090..10312232, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (10340779..10342921, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

nog1, a bone morphogenetic protein antagonist expressed in gastrulation, is dispensable for neural crest induction. induction.
Title: Signals derived from the underlying mesoderm are dispensable for zebrafish neural crest induction.
While Chordin is the main player of the D/V axis, the structures remaining in the chd mutant in both mesodermal and ectodermal layers) result from the anti-Bmp activity carried by Nog1 and Fstl2 at blastula and gastrula stages.
Title: Noggin1 and Follistatin-like2 function redundantly to Chordin to antagonize BMP activity.

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General gene information

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Markers

fc23h06.x1 (e-PCR)
- UniSTS:203894

nog1 (e-PCR), detects polymorphism
- UniSTS:205560

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cartilage development	IEA Inferred from Electronic Annotation more info
involved_in cartilage development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in dorsal/ventral pattern formation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of BMP signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within negative regulation of cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of endodermal cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in osteoblast differentiation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: noggin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.