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    dazl deleted in azoospermia-like [ Danio rerio (zebrafish) ]

    Gene ID: 58039, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dazlprovided by ZNC
    Official Full Name
    deleted in azoospermia-likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000405-6
    See related
    Ensembl:ENSDARG00000036214 AllianceGenome:ZFIN:ZDB-GENE-000405-6
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Enables mRNA 3'-UTR binding activity; sequence-specific DNA binding activity; and translation activator activity. Acts upstream of or within 3'-UTR-mediated mRNA stabilization and negative regulation of miRNA-mediated gene silencing. Located in cytoplasm. Is expressed in several structures, including blastodisc; germ line cell; gonad; unfertilized egg; and yolk. Orthologous to several human genes including DAZL (deleted in azoospermia like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dazl in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (20389104..20403867, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (20804781..20819548, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene oxidoreductase NAD-binding domain containing 1 Neighboring gene raftlin, lipid raft linker 1a Neighboring gene TBC1 domain family, member 5 Neighboring gene SATB homeobox 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish DAZ-like protein controls translation via the sequence 'GUUC'. Maegawa S, et al. Genes Cells, 2002 Sep. PMID 12296827
    2. Methods for the analysis of early oogenesis in Zebrafish. Elkouby YM, et al. Dev Biol, 2017 Oct 15. PMID 27988227, Free PMC Article
    3. Microtubule-actin crosslinking factor 1 (Macf1) domain function in Balbiani body dissociation and nuclear positioning. Escobar-Aguirre M, et al. PLoS Genet, 2017 Sep. PMID 28880872, Free PMC Article
    4. Microtubule actin crosslinking factor 1 regulates the Balbiani body and animal-vegetal polarity of the zebrafish oocyte. Gupta T, et al. PLoS Genet, 2010 Aug 19. PMID 20808893, Free PMC Article
    5. Multigenerational consequences of early-life cannabinoid exposure in zebrafish. Carty DR, et al. Toxicol Appl Pharmacol, 2019 Feb 1. PMID 30594692, Free PMC Article

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zebrafish dazl regulates cystogenesis and germline stem cell specification during the primordial germ cell to germline stem cell transition.
      Title: Zebrafish dazl regulates cystogenesis and germline stem cell specification during the primordial germ cell to germline stem cell transition.
    2. Cortical depth and differential transport of vegetally localized dorsal and germ line determinants, Wnt8a, grip2a, and Dazl, in the zebrafish embryo have been presented.
      Title: Cortical depth and differential transport of vegetally localized dorsal and germ line determinants in the zebrafish embryo.
    3. that DAZL specifically binds the HuB 3'UTR and protects the message from degradation and/or enhances HuB translation, leading to the germ cell specific expression of HuB protein.
      Title: HuB (elavl2) mRNA is restricted to the germ cells by post-transcriptional mechanisms including stabilisation of the message by DAZL.
    4. DAZL relieves miRNA-mediated repression of germline mRNAs by controlling poly(A) tail length in zebrafish
      Title: DAZL relieves miRNA-mediated repression of germline mRNAs by controlling poly(A) tail length in zebrafish.
    5. Data show that DAZ-like protein directly promotes the translation of the target mRNAs in vertebrates.
      Title: Zebrafish DAZ-like protein controls translation via the sequence 'GUUC'.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA 3'-UTR binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables translation activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within 3'-UTR-mediated mRNA stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within germ-line cyst formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of miRNA-mediated gene silencing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within oogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    deleted in azoospermia-like
    Names
    DAZ-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131524.1 → NP_571599.1  deleted in azoospermia-like

      See identical proteins and their annotated locations for NP_571599.1

      Status: PROVISIONAL

      Source sequence(s)
      AB018191
      UniProtKB/Swiss-Prot
      Q9YGW7
      Related
      ENSDARP00000113712.1, ENSDART00000137590.3
      Conserved Domains (2) summary
      COG0724
      Location:40 → 132
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12672
      Location:42 → 123
      RRM_DAZL; RNA recognition motif in vertebrate deleted in azoospermia-like (DAZL) proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      20389104..20403867 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005170072.5 → XP_005170129.1  deleted in azoospermia-like isoform X2

      See identical proteins and their annotated locations for XP_005170129.1

      UniProtKB/TrEMBL
      A0A8M2BHE4, Q1LUN5
      Related
      ENSDARP00000121099.1, ENSDART00000147911.3
      Conserved Domains (2) summary
      COG0724
      Location:23 → 115
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12672
      Location:25 → 106
      RRM_DAZL; RNA recognition motif in vertebrate deleted in azoospermia-like (DAZL) proteins

    2. XM_005170071.4 → XP_005170128.1  deleted in azoospermia-like isoform X2

      See identical proteins and their annotated locations for XP_005170128.1

      UniProtKB/TrEMBL
      A0A8M2BHE4, Q1LUN5
      Conserved Domains (2) summary
      COG0724
      Location:23 → 115
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12672
      Location:25 → 106
      RRM_DAZL; RNA recognition motif in vertebrate deleted in azoospermia-like (DAZL) proteins

    3. XM_005170070.5 → XP_005170127.1  deleted in azoospermia-like isoform X1

      UniProtKB/TrEMBL
      A0A8M2BHE7, Q1LUN6
      Related
      ENSDARP00000052602.3, ENSDART00000052603.5
      Conserved Domains (2) summary
      COG0724
      Location:40 → 132
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12672
      Location:42 → 123
      RRM_DAZL; RNA recognition motif in vertebrate deleted in azoospermia-like (DAZL) proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9YGW7.1 GenPept UniProtKB/Swiss-Prot:Q9YGW7

    Gene LinkOut

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