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    tollip toll interacting protein [ Danio rerio (zebrafish) ]

    Gene ID: 336876, updated on 2-Nov-2024

    Summary

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    Official Symbol
    tollipprovided by ZNC
    Official Full Name
    toll interacting proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8820
    See related
    Ensembl:ENSDARG00000098486 AllianceGenome:ZFIN:ZDB-GENE-030131-8820
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fk22a02; zgc:76985; im:7145391; wu:fk22a02
    Summary
    Predicted to enable ubiquitin binding activity and ubiquitin conjugating enzyme binding activity. Acts upstream of or within negative regulation of Wnt signaling pathway. Predicted to be located in early endosome. Predicted to be active in cytoplasm. Orthologous to human TOLLIP (toll interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tollip in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (72276507..72290604)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (72027216..72041313)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene signal-induced proliferation-associated 1 Neighboring gene RAS guanyl-releasing protein 2 Neighboring gene solute carrier family 35 member C1 Neighboring gene intestinal mucin-like protein Neighboring gene mucin-2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization and expression analysis of Toll-interacting protein in common carp, Cyprinus carpio L., responding to bacterial and viral challenge. Shan S, et al. Springerplus, 2016. PMID 27330905, Free PMC Article
    2. Endocytic Adaptor Protein Tollip Inhibits Canonical Wnt Signaling. Toruń A, et al. PLoS One, 2015. PMID 26110841, Free PMC Article
    3. Tollip-deficient zebrafish display no abnormalities in development, organ morphology or gene expression in response to lipopolysaccharide. Wolińska-Nizioł L, et al. FEBS Open Bio, 2022 Aug. PMID 35506194, Free PMC Article
    4. Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish. Stein C, et al. Genome Biol, 2007. PMID 18039395, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    toll-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328590.1 → NP_001315519.1  toll-interacting protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      CU463038, EH451009, EH562339, EH573127
      UniProtKB/Swiss-Prot
      Q6NYL4, Q7ZV43
      UniProtKB/TrEMBL
      A0A0R4IVK4, A0A8M1PAH8
      Related
      ENSDARP00000138745.1, ENSDART00000166544.2
      Conserved Domains (2) summary
      cd04016
      Location:28 → 148
      C2_Tollip; C2 domain present in Toll-interacting protein (Tollip)
      cd14363
      Location:208 → 248
      CUE_TOLIP; CUE domain found in the C-terminal of toll-interacting protein (Tollip) and similar proteins

    2. NM_207061.2 → NP_996944.2  toll-interacting protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      EH448242, EH562339, EH573127
      UniProtKB/Swiss-Prot
      Q6NYL4, Q7ZV43
      UniProtKB/TrEMBL
      A0A0R4IZ33, A0A8N1TZ91
      Related
      ENSDARP00000140869.1, ENSDART00000172021.2

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      72276507..72290604
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZV43.1 GenPept UniProtKB/Swiss-Prot:Q7ZV43

    Gene LinkOut

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