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    kmt2ba lysine (K)-specific methyltransferase 2Ba [ Danio rerio (zebrafish) ]

    Gene ID: 560856, updated on 14-Nov-2024

    Summary

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    Official Symbol
    kmt2baprovided by ZNC
    Official Full Name
    lysine (K)-specific methyltransferase 2Baprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060503-376
    See related
    Ensembl:ENSDARG00000062962 AllianceGenome:ZFIN:ZDB-GENE-060503-376
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mll4a; si:rp71-15k1.2
    Summary
    Predicted to enable histone H3K4 methyltransferase activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to act upstream of or within chromatin organization and methylation. Predicted to be located in nucleus. Predicted to be part of histone methyltransferase complex. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; colorectal adenocarcinoma; dystonia 28, childhood-onset; and hepatocellular carcinoma. Orthologous to human KMT2B (lysine methyltransferase 2B). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See kmt2ba in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (9232678..9275240)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (9313048..9356315)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase core subunit V1 Neighboring gene transfer RNA methionine (anticodon CAU) Neighboring gene si:rp71-15k1.1 Neighboring gene si:ch73-15n24.1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The DEAD-box RNA helicase Ddx39ab is essential for myocyte and lens development in zebrafish. Zhang L, et al. Development, 2018 Apr 23. PMID 29636379
    2. Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes. Sun XJ, et al. PLoS One, 2008 Jan 30. PMID 18231586, Free PMC Article
    3. The Kdm/Kmt gene families in the self-fertilizing mangrove rivulus fish, Kryptolebias marmoratus, suggest involvement of histone methylation machinery in development and reproduction. Fellous A, et al. Gene, 2019 Mar 1. PMID 30458291
    4. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K4 monomethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase 2B
    Names
    myeloid/lymphoid or mixed-lineage leukemia 4a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      9232678..9275240
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_684255.10 → XP_689347.5  histone-lysine N-methyltransferase 2B isoform X3

      UniProtKB/TrEMBL
      A0A8N7TDQ0
      Related
      ENSDARP00000113465.2, ENSDART00000136957.3
      Conserved Domains (7) summary
      cd05493
      Location:1187 → 1334
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00317
      Location:2725 → 2845
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG2940
      Location:2677 → 2863
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      pfam02008
      Location:780 → 823
      zf-CXXC; CXXC zinc finger domain
      pfam05964
      Location:1540 → 1586
      FYRN; F/Y-rich N-terminus
      cl02651
      Location:2561 → 2646
      FYRC; F/Y rich C-terminus
      cl22851
      Location:1389 → 1492
      PHD_SF; PHD finger superfamily

    2. XM_068215240.1 → XP_068071341.1  histone-lysine N-methyltransferase 2B isoform X1

      Related
      ENSDARP00000147918.1, ENSDART00000190617.1

    3. XM_005159485.5 → XP_005159542.1  histone-lysine N-methyltransferase 2B isoform X4

      UniProtKB/TrEMBL
      A0A8M2B683
      Conserved Domains (7) summary
      cd05493
      Location:1186 → 1333
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00317
      Location:2724 → 2844
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG2940
      Location:2676 → 2862
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      pfam02008
      Location:780 → 823
      zf-CXXC; CXXC zinc finger domain
      pfam05964
      Location:1539 → 1585
      FYRN; F/Y-rich N-terminus
      cl02651
      Location:2560 → 2645
      FYRC; F/Y rich C-terminus
      cl22851
      Location:1388 → 1491
      PHD_SF; PHD finger superfamily

    4. XM_068215241.1 → XP_068071342.1  histone-lysine N-methyltransferase 2B isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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