mrpl12 mitochondrial ribosomal protein L12 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mrpl12provided by ZNC
Official Full Name: mitochondrial ribosomal protein L12provided by ZNC
Primary source: ZFIN:ZDB-GENE-050417-187
See related: Ensembl:ENSDARG00000038768 AllianceGenome:ZFIN:ZDB-GENE-050417-187
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:6893415; zgc:112445
Summary: Predicted to enable mRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial large ribosomal subunit. Is expressed in several structures, including alar plate midbrain region; digestive system; optic tectum; optic vesicle; and pectoral fin. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 45. Orthologous to human MRPL12 (mitochondrial ribosomal protein L12). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (50054372..50066499, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (49018919..49031239, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb01a02.y1 (e-PCR)
- UniSTS:189768

fk52g11.x1 (e-PCR)
- UniSTS:201128

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in translation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of mitochondrial large ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in ribosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: large ribosomal subunit protein bL12m

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017696.1 → NP_001017696.1 large ribosomal subunit protein bL12m

See identical proteins and their annotated locations for NP_001017696.1

Status: PROVISIONAL

Source sequence(s)

BC093312

UniProtKB/TrEMBL

A0A8M1N572, Q566V8

Related

ENSDARP00000056617.2, ENSDART00000056618.4

Conserved Domains (2) summary

cd00387
Location:60 → 193

Ribosomal_L7_L12; Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of ...

CHL00083
Location:59 → 193

rpl12; ribosomal protein L12

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

50054372..50066499 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009299749.4 → XP_009298024.1 large ribosomal subunit protein bL12m isoform X1

UniProtKB/TrEMBL

A0A8M3B196, X1WHQ5

Related

ENSDARP00000129769.1, ENSDART00000154561.3

Conserved Domains (2) summary

cd00387
Location:60 → 198

Ribosomal_L7_L12; Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of ...

CHL00083
Location:59 → 198

rpl12; ribosomal protein L12