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    fas Fas cell surface death receptor [ Danio rerio (zebrafish) ]

    Gene ID: 768248, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fasprovided by ZNC
    Official Full Name
    Fas cell surface death receptorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061019-2
    See related
    Ensembl:ENSDARG00000043586 AllianceGenome:ZFIN:ZDB-GENE-061019-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable tumor necrosis factor receptor activity. Acts upstream of or within notochord development and positive regulation of apoptotic process. Predicted to be located in plasma membrane. Predicted to be part of CD95 death-inducing signaling complex. Predicted to be active in external side of plasma membrane and membrane raft. Is expressed in several structures, including blastoderm; digestive system; eye; notochord; and ovary. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hematologic cancer (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Orthologous to human FAS (Fas cell surface death receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See fas in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (23618899..23631411, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (23599896..23611375, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene interferon-induced protein with tetratricopeptide repeats 15 Neighboring gene interferon-induced protein with tetratricopeptide repeats 14 Neighboring gene phosphatase and tensin homolog A Neighboring gene 3'-phosphoadenosine 5'-phosphosulfate synthase 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Effects of short term lead exposure on gut microbiota and hepatic metabolism in adult zebrafish. Xia J, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2018 Jul. PMID 29574035
    2. FAS/FASL are dysregulated in chordoma and their loss-of-function impairs zebrafish notochord formation. Ferrari L, et al. Oncotarget, 2014 Jul 30. PMID 25071022, Free PMC Article
    3. EFTUD2 gene deficiency disrupts osteoblast maturation and inhibits chondrocyte differentiation via activation of the p53 signaling pathway. Wu J, et al. Hum Genomics, 2019 Dec 5. PMID 31806011, Free PMC Article
    4. Methylnitrosourea, dimethylbenzanthracene and benzoapyrene differentially affect redox pathways, apoptosis and immunity in zebrafish. Eğimezer G, et al. Hum Exp Toxicol, 2020 Jul. PMID 32054343
    5. Disruption of apoptosis pathways involved in zebrafish gonad differentiation by 17α-ethinylestradiol and fadrozole exposures. Luzio A, et al. Aquat Toxicol, 2016 Aug. PMID 27337697

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within notochord development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within notochord development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily member 26
    Names
    Fas (TNF receptor superfamily, member 6)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      23618899..23631411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021467407.2 → XP_021323082.1  tumor necrosis factor receptor superfamily member 6

      UniProtKB/TrEMBL
      A0A8M9P0K2, F1QG24
      Related
      ENSDARP00000074016.4, ENSDART00000079563.6
      Conserved Domains (2) summary
      cd08316
      Location:200 → 292
      Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
      cd13423
      Location:28 → 129
      TNFRSF6_teleost; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6) in teleosts; also known as fas cell surface death receptor (FasR)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395331.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      224409..234831 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_685355.8 → XP_690447.5  tumor necrosis factor receptor superfamily member 26

      UniProtKB/TrEMBL
      A0A8N7UR03
      Conserved Domains (2) summary
      cd08316
      Location:201 → 293
      Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
      cd13423
      Location:28 → 129
      TNFRSF6_teleost; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6) in teleosts; also known as fas cell surface death receptor (FasR)
    Nucleotide Protein Strain
    Heading Accession and Version

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