tlx2 T cell leukemia homeobox 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tlx2provided by ZNC
Official Full Name: T cell leukemia homeobox 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-020208-1
See related: Ensembl:ENSDARG00000011273 AllianceGenome:ZFIN:ZDB-GENE-020208-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tlxA; tlx3a; Tlx-3a; hox11l
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within inner ear development. Predicted to be active in nucleus. Is expressed in Rohon-Beard neurons; inner ear; and statoacoustic (VIII) ganglion. Orthologous to human TLX2 (T cell leukemia homeobox 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (5656679..5678461, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (5349845..5371645, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

identification and expression patterns of three members of the zebrafish Tlx family
Title: Molecular cloning and developmental expression of Tlx (Hox11) genes in zebrafish (Danio rerio).

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in animal organ development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inner ear development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: T-cell leukemia homeobox protein 2

Names: T-cell leukemia, homeobox 3a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153651.2 → NP_705937.2 T-cell leukemia homeobox protein 2

See identical proteins and their annotated locations for NP_705937.2

Status: PROVISIONAL

Source sequence(s)

BC128814

UniProtKB/TrEMBL

A0A8M1P7S8, A1A5U3

Related

ENSDARP00000009610.6, ENSDART00000012116.8

Conserved Domains (1) summary

pfam00046
Location:185 → 238

Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007125.7 Reference GRCz11 Primary Assembly

Range

5656679..5678461 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005173082.5 → XP_005173139.1 T-cell leukemia homeobox protein 2 isoform X1

UniProtKB/TrEMBL

A0A2R8QHC0, A0A8M2BKC9

Related

ENSDARP00000153385.1, ENSDART00000182156.1

Conserved Domains (1) summary

pfam00046
Location:185 → 238

Homeobox; Homeobox domain