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    SRP9 signal recognition particle 9 [ Homo sapiens (human) ]

    Gene ID: 6726, updated on 3-Nov-2024

    Summary

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    Official Symbol
    SRP9provided by HGNC
    Official Full Name
    signal recognition particle 9provided by HGNC
    Primary source
    HGNC:HGNC:11304
    See related
    Ensembl:ENSG00000143742 MIM:600707; AllianceGenome:HGNC:11304
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ALURBP
    Summary
    Predicted to enable RNA binding activity and signal recognition particle binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane. Predicted to be located in cytosol. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal (RPKM 131.7), brain (RPKM 102.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SRP9 in Genome Data Viewer
    Location:
    1q42.12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (225777826..225790464)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (224965843..224978462)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (225965528..225978166)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985352 Neighboring gene RNA, U6 small nuclear 1304, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:225938191-225938690 Neighboring gene uncharacterized LOC124904527 Neighboring gene VISTA enhancer hs2374 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:225956009-225956180 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_5770 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:225964521-225965281 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2629 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:225969251-225969750 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1859 Neighboring gene left-right determination factor 3, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:226004679-226005506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:226005507-226006333 Neighboring gene epoxide hydrolase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:226012583-226013259 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:226015269-226016122 Neighboring gene transmembrane protein 63A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Investigation of SRP9 protein expression in breast cancer. Erdoğan G, et al. Mol Biol Rep, 2022 Jan. PMID 34727289
    2. Human signal recognition particle (SRP) Alu-associated protein also binds Alu interspersed repeat sequence RNAs. Characterization of human SRP9. Hsu K, et al. J Biol Chem, 1995 Apr 28. PMID 7730321
    3. Compartmentalization directs assembly of the signal recognition particle. Maity TS, et al. Biochemistry, 2006 Dec 19. PMID 17154533
    4. Assembly of the Alu domain of the signal recognition particle (SRP): dimerization of the two protein components is required for efficient binding to SRP RNA. Strub K, et al. Mol Cell Biol, 1990 Feb. PMID 2153922, Free PMC Article
    5. Alu RNA regulates the cellular pool of active ribosomes by targeted delivery of SRP9/14 to 40S subunits. Ivanova E, et al. Nucleic Acids Res, 2015 Mar 11. PMID 25697503, Free PMC Article

    See all (119) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Significance of signal recognition particle 9 nuclear translocation: Implications for pancreatic cancer prognosis and functionality.
      Title: Significance of signal recognition particle 9 nuclear translocation: Implications for pancreatic cancer prognosis and functionality.
    2. Investigation of SRP9 protein expression in breast cancer.
      Title: Investigation of SRP9 protein expression in breast cancer.
    3. Dats show that Alu RNA promotes functional binding of Signal Recognition Particle proteins SRP9/14 to 40S ribosomal subunits.
      Title: Alu RNA regulates the cellular pool of active ribosomes by targeted delivery of SRP9/14 to 40S subunits.
    4. mutational study on SRP9/14 that identified and characterized regions and single residues essential for elongation arrest activity
      Title: Residues in SRP9/14 essential for elongation arrest activity of the signal recognition particle define a positively charged functional domain on one side of the protein.
    5. PSB7, PRDX1, and SRP9 up-regulation as candidate biomarkers of colon cancer is discovered
      Title: Proteomic expression analysis of surgical human colorectal cancer tissues: up-regulation of PSB7, PRDX1, and SRP9 and hypoxic adaptation in cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Downregulation of guanine nucleotide-releasing protein, CD151/PETA-3, neuronatin, neuroendocrine differentiation factor, mitochondria 16s rRNA, and signal recognition particle is observed in HIV-1 infected and HIV-1 gp120-treated astrocytes PubMed
    Rev rev HIV-1 Rev interacting protein, signal recognition particle 9kDa (SRP9), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with SRP9 is increased by RRE PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC110981

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 7S RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signal recognition particle binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of signal recognition particle receptor complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of signal recognition particle, endoplasmic reticulum targeting IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal recognition particle, endoplasmic reticulum targeting NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    signal recognition particle 9 kDa protein
    Names
    signal recognition particle 9kD
    signal recognition particle 9kDa
    NP_001123912.1
    NP_003124.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130440.2 → NP_001123912.1  signal recognition particle 9 kDa protein isoform 1

      See identical proteins and their annotated locations for NP_001123912.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript but encodes the shorter isoform (1).
      Source sequence(s)
      BC021995, DA983529, EF488978
      Consensus CDS
      CCDS44323.1
      Related
      ENSP00000355804.4, ENST00000366839.8
      Conserved Domains (1) summary
      pfam05486
      Location:4 → 51
      SRP9-21; Signal recognition particle 9 kDa protein (SRP9)

    2. NM_003133.6 → NP_003124.1  signal recognition particle 9 kDa protein isoform 2

      See identical proteins and their annotated locations for NP_003124.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal exon, as compared to variant 1. The resulting isoform (2) has a longer and distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      BC008443, BC021995, DA983529
      Consensus CDS
      CCDS1546.1
      UniProtKB/Swiss-Prot
      A8K0N0, P49458, Q6NVX0, Q8WTW0
      Related
      ENSP00000305230.7, ENST00000304786.12
      Conserved Domains (1) summary
      pfam05486
      Location:4 → 73
      SRP9-21; Signal recognition particle 9 kDa protein (SRP9)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      225777826..225790464
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      224965843..224978462
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49458.2 GenPept UniProtKB/Swiss-Prot:P49458

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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