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    RANBP1 RAN binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 5902, updated on 26-Nov-2024

    Summary

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    Official Symbol
    RANBP1provided by HGNC
    Official Full Name
    RAN binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:9847
    See related
    Ensembl:ENSG00000099901 MIM:601180; AllianceGenome:HGNC:9847
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HTF9A
    Summary
    This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
    Expression
    Ubiquitous expression in testis (RPKM 15.4), lymph node (RPKM 10.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RANBP1 in Genome Data Viewer
    Location:
    22q11.21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (20116104..20127355)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (20495154..20506390)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (20103627..20114878)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene DGCR8 microprocessor complex subunit Neighboring gene microRNA 1306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20099501-20100000 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13474 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13475 Neighboring gene tRNA methyltransferase 2 homolog A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13476 Neighboring gene microRNA 6816 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18671 Neighboring gene small nucleolar RNA, H/ACA box 77B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13477 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13478 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:20119547-20120200 Neighboring gene zinc finger DHHC-type palmitoyltransferase 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20125107-20125706 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13481 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13482 Neighboring gene coiled-coil domain containing 188

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Stimulation of nuclear export and inhibition of nuclear import by a Ran mutant deficient in binding to Ran-binding protein 1. Kehlenbach RH, et al. J Biol Chem, 2001 Apr 27. PMID 11278834
    2. RANBP1 localizes a subset of mitotic regulatory factors on spindle microtubules and regulates chromosome segregation in human cells. Tedeschi A, et al. J Cell Sci, 2007 Nov 1. PMID 17940066
    3. Different structural and kinetic requirements for the interaction of Ran with the Ran-binding domains from RanBP2 and importin-beta. Villa Braslavsky CI, et al. Biochemistry, 2000 Sep 26. PMID 10995230
    4. Association of RANBP1 haplotype with smooth pursuit eye movement abnormality. Cheong HS, et al. Am J Med Genet B Neuropsychiatr Genet, 2011 Jan. PMID 21184585
    5. Characterization of Ran-driven cargo transport and the RanGTPase system by kinetic measurements and computer simulation. Görlich D, et al. EMBO J, 2003 Mar 3. PMID 12606574, Free PMC Article

    See all (153) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CD147 supports paclitaxel resistance via interacting with RanBP1.
      Title: CD147 supports paclitaxel resistance via interacting with RanBP1.
    2. Oxidative stress and signaling through EGFR and PKA pathways converge on the nuclear transport factor RanBP1.
      Title: Oxidative stress and signaling through EGFR and PKA pathways converge on the nuclear transport factor RanBP1.
    3. RanBP1: A Potential Therapeutic Target for Cancer Stem Cells in Lung Cancer and Glioma.
      Title: RanBP1: A Potential Therapeutic Target for Cancer Stem Cells in Lung Cancer and Glioma.
    4. RanBP1 controls the Ran pathway in mammalian cells through regulation of mitotic RCC1 dynamics.
      Title: RanBP1 controls the Ran pathway in mammalian cells through regulation of mitotic RCC1 dynamics.
    5. Sgk1-dependent regulation of RANBP1 has functional consequences on both mitotic microtubule activity and taxol sensitivity of cancer cells.
      Title: Sgk1 enhances RANBP1 transcript levels and decreases taxol sensitivity in RKO colon carcinoma cells.
    6. in vitro and in vivo phosphorylation of RanBP1 by Plk1 as well as the importance of phosphorylation of RanBP1 in the interaction between Plk1 and Ran during early mitosis, is demonstrated.
      Title: Phosphorylation of Ran-binding protein-1 by Polo-like kinase-1 is required for interaction with Ran and early mitotic progression.
    7. RANBP1 on 22q11.21 locus might be causally related to the smooth pursuit eye movement abnormality rather than the development of schizophrenia.
      Title: Association of RANBP1 haplotype with smooth pursuit eye movement abnormality.
    8. Downregulation of the Ran GTPase effector RanBP1 is required for nuclear reorganisation.
      Title: Nuclear reformation after mitosis requires downregulation of the Ran GTPase effector RanBP1 in mammalian cells.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: Centrosome-related genes, genetic variation, and risk of breast cancer.
    10. Generation of Ran-GTP from Ran-GDP by importin-beta is activated by Ran-binding protein-1 (RanBP1) that forms a trimeric complex with Ran-GDP and importin-beta.
      Title: Importin-beta is a GDP-to-GTP exchange factor of Ran: implications for the mechanism of nuclear import.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of RAN binding protein 1 (RANBP1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev RanBP1 competes with Rev for the same nuclear export pathway and as a result can affect Rev-mediated nuclear export of HIV-1 mRNA PubMed
    Vpu vpu HIV-1 Vpu is identified to have a physical interaction with RAN binding protein 1 (RANBP1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GDP-dissociation inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cadherin binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nucleocytoplasmic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mitotic centrosome separation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nuclear envelope TAS
    Traceable Author Statement
    more info
    		  
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ran-specific GTPase-activating protein
    Names
    HpaII tiny fragments locus 9A
    testis secretory sperm-binding protein Li 221n

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278639.2 → NP_001265568.1  ran-specific GTPase-activating protein isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AW404614, CA489474, DC397929, HY229989, X83617
      Consensus CDS
      CCDS74823.1
      UniProtKB/TrEMBL
      F6WQW2
      Related
      ENSP00000401564.2, ENST00000430524.6
      Conserved Domains (1) summary
      cd13179
      Location:101 → 237
      RanBD_RanBP1; Ran-binding domain

    2. NM_001278640.2 → NP_001265569.1  ran-specific GTPase-activating protein isoform 3

      See identical proteins and their annotated locations for NP_001265569.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains multiple differences, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AW404614, D38076, HY229989
      Consensus CDS
      CCDS63408.1
      UniProtKB/Swiss-Prot
      P43487
      Related
      ENSP00000384925.1, ENST00000402752.5
      Conserved Domains (1) summary
      cd13179
      Location:24 → 160
      RanBD_RanBP1; Ran-binding domain

    3. NM_001278641.2 → NP_001265570.1  ran-specific GTPase-activating protein isoform 4

      See identical proteins and their annotated locations for NP_001265570.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains multiple differences, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (4) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC006547, AW404614, BG717186, BI916757, HY229989
      UniProtKB/TrEMBL
      C9JXG8
      Related
      ENSP00000413502.2, ENST00000418705.2
      Conserved Domains (1) summary
      cd13179
      Location:1 → 110
      RanBD_RanBP1; Ran-binding domain

    4. NM_002882.4 → NP_002873.1  ran-specific GTPase-activating protein isoform 2

      See identical proteins and their annotated locations for NP_002873.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AW404614, DB459798, HY229989, X83617
      Consensus CDS
      CCDS13775.1
      UniProtKB/Swiss-Prot
      P43487, Q53EY3
      UniProtKB/TrEMBL
      A0A140VK94
      Related
      ENSP00000327583.3, ENST00000331821.8
      Conserved Domains (1) summary
      cd13179
      Location:24 → 160
      RanBD_RanBP1; Ran-binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      20116104..20127355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011530289.4 → XP_011528591.1  ran-specific GTPase-activating protein isoform X1

      See identical proteins and their annotated locations for XP_011528591.1

      UniProtKB/TrEMBL
      B4DE76, B7Z6U1
      Conserved Domains (1) summary
      cd13179
      Location:24 → 146
      RanBD_RanBP1; Ran-binding domain

    2. XM_017028892.2 → XP_016884381.1  ran-specific GTPase-activating protein isoform X3

      UniProtKB/TrEMBL
      C9JXG8
      Conserved Domains (1) summary
      cd13179
      Location:1 → 110
      RanBD_RanBP1; Ran-binding domain

    3. XM_011530290.3 → XP_011528592.1  ran-specific GTPase-activating protein isoform X2

      See identical proteins and their annotated locations for XP_011528592.1

      UniProtKB/TrEMBL
      B3KUP2
      Conserved Domains (1) summary
      cl17171
      Location:14 → 70
      PH-like; Pleckstrin homology-like domain

    4. XM_047441451.1 → XP_047297407.1  ran-specific GTPase-activating protein isoform X5

    5. XM_047441450.1 → XP_047297406.1  ran-specific GTPase-activating protein isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      20495154..20506390
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325804.1 → XP_054181779.1  ran-specific GTPase-activating protein isoform X1

      UniProtKB/TrEMBL
      B4DE76

    2. XM_054325806.1 → XP_054181781.1  ran-specific GTPase-activating protein isoform X3

    3. XM_054325805.1 → XP_054181780.1  ran-specific GTPase-activating protein isoform X2

      UniProtKB/TrEMBL
      B3KUP2

    4. XM_054325808.1 → XP_054181783.1  ran-specific GTPase-activating protein isoform X5

    5. XM_054325807.1 → XP_054181782.1  ran-specific GTPase-activating protein isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43487.1 GenPept UniProtKB/Swiss-Prot:P43487

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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