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    CLDN10 claudin 10 [ Homo sapiens (human) ]

    Gene ID: 9071, updated on 9-Dec-2024

    Summary

    Official Symbol
    CLDN10provided by HGNC
    Official Full Name
    claudin 10provided by HGNC
    Primary source
    HGNC:HGNC:2033
    See related
    Ensembl:ENSG00000134873 MIM:617579; AllianceGenome:HGNC:2033
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OSPL; HELIX; OSP-L; CPETRL3
    Summary
    This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The expression level of this gene is associated with recurrence of primary hepatocellular carcinoma. Six alternatively spliced transcript variants encoding different isoforms have been reported, but the transcript sequences of some variants are not determined.[provided by RefSeq, Jun 2010]
    Expression
    Biased expression in kidney (RPKM 32.5), salivary gland (RPKM 18.3) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CLDN10 in Genome Data Viewer
    Location:
    13q32.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (95433755..95579759)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (94638308..94784309)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (96086009..96232013)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903193 Neighboring gene RNY4 pseudogene 27 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5440 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7876 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5441 Neighboring gene MEMO1 pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7877 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7878 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7879 Neighboring gene CLDN10 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:96144450-96144950 Neighboring gene Sharpr-MPRA regulatory region 5370 Neighboring gene Sharpr-MPRA regulatory region 2339 Neighboring gene DAZ interacting zinc finger protein 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:96294105-96295030 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5443 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5444 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5445 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7880 Neighboring gene uncharacterized LOC124903194 Neighboring gene H3K27ac hESC enhancers GRCh37_chr13:96328483-96329330 and GRCh37_chr13:96329331-96330177 Neighboring gene DNAJC3 divergent transcript

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef The yeast two-hybrid screen identifies the HIV-1 Nef interacting human protein claudin 10 (CLDN10), which co-localizes with Nef mainly in the tight junction region and at the vesicular structures PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables paracellular tight junction channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in bicellular tight junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in paracellular transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of monoatomic ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in bicellular tight junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    claudin-10
    Names
    OSP-like protein
    oligodendrocyte-specific protein-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047100.1 RefSeqGene

      Range
      124122..151161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001160100.2NP_001153572.1  claudin-10 isoform a_i1

      See identical proteins and their annotated locations for NP_001153572.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (a_v1) uses an alternate in-frame splice site in the 5' coding region, compared to variant a. The resulting isoform (a_i1) lacks an internal segment near the N-terminus, compared to isoform a.
      Source sequence(s)
      AK055855, AL139376, BG697724, DB544708
      UniProtKB/Swiss-Prot
      P78369
      Conserved Domains (1) summary
      cl21598
      Location:9158
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
    2. NM_006984.5NP_008915.1  claudin-10 isoform b

      See identical proteins and their annotated locations for NP_008915.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b) differs in the 5' UTR and 5' coding region, representing use of an alternate promoter, compared to variant a. The resulting isoform (b) has a longer and distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AK055855, AL139376, BC010920, BG697724, DA133712, DB544708
      Consensus CDS
      CCDS9476.1
      UniProtKB/Swiss-Prot
      P78369, Q6IBF9, Q96N78
      Related
      ENSP00000299339.2, ENST00000299339.3
      Conserved Domains (1) summary
      pfam00822
      Location:4179
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
    3. NM_182848.4NP_878268.1  claudin-10 isoform a

      See identical proteins and their annotated locations for NP_878268.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (a) represents the longest transcript and encodes isoform a.
      Source sequence(s)
      AK055855, AL139376, BG697724, DB544708
      Consensus CDS
      CCDS9475.1
      UniProtKB/Swiss-Prot
      P78369
      Related
      ENSP00000366069.2, ENST00000376873.7
      Conserved Domains (1) summary
      cl21598
      Location:9177
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      95433755..95579759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430765.1XP_047286721.1  claudin-10 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      94638308..94784309
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375166.1XP_054231141.1  claudin-10 isoform X1