ACE2 DNA-binding transcription factor ACE2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: ACE2
Gene description: DNA-binding transcription factor ACE2
Primary source: FungiDB:YLR131C
Locus tag: YLR131C
See related: SGD:S000004121; AllianceGenome:SGD:S000004121; VEuPathDB:YLR131C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of septum digestion after cytokinesis and regulation of transcription, DNA-templated. Located in cytosol and nucleus. Orthologous to human KLF10 (Kruppel like factor 10). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ACE2 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (404510..406822, complement)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Asymmetric Transcription Factor Partitioning During Yeast Cell Division Requires the FACT Chromatin Remodeler and Cell Cycle Progression.
Title: Asymmetric Transcription Factor Partitioning During Yeast Cell Division Requires the FACT Chromatin Remodeler and Cell Cycle Progression.
ACE2, a transcription factor required for septum destruction after cytokinesis, is a negative regulator of ethanol tolerance.
Title: Identifying and characterizing SCRaMbLEd synthetic yeast using ReSCuES.
Therefore, Ace2 and Swi5 are two negative regulators of ethanol yield during static fermentation of yeast cells, and both CTS1 and RPS4a are major effectors mediating these two transcription factors in regulating ethanol production.
Title: The transcription factor Ace2 and its paralog Swi5 regulate ethanol production during static fermentation through their targets Cts1 and Rps4a in Saccharomyces cerevisiae.
Data show that mutation of the Rts1 regulatory subunit of PP2A phosphatase (PP2ARts1 phosphatase) results in decreased HO endonuclease expression due to altered localization of the Ace2 transcription factor.
Title: The Rts1 regulatory subunit of PP2A phosphatase controls expression of the HO endonuclease via localization of the Ace2 transcription factor.
Genome duplication and mutations in ACE2 cause multicellular, fast-sedimenting phenotypes in evolved Saccharomyces cerevisiae.
Title: Genome duplication and mutations in ACE2 cause multicellular, fast-sedimenting phenotypes in evolved Saccharomyces cerevisiae.
show that Ace2 asymmetry is initiated in the elongated, but undivided, anaphase nucleus
Title: Nuclear envelope morphology constrains diffusion and promotes asymmetric protein segregation in closed mitosis.
we discovered previously unrecognized levels of regulation of the Ace2 transcription factor and the cyclin-dependent protein kinase inhibitor Sic1
Title: New insight into the role of the Cdc34 ubiquitin-conjugating enzyme in cell cycle regulation via Ace2 and Sic1.
Data show that Ace2's nuclear localization is maintained by continuous Cbk1 activity and that inhibition of the kinase leads to immediate loss of phosphorylation and export to the cytoplasm.
Title: Sequential counteracting kinases restrict an asymmetric gene expression program to early G1.
Regulation of CLN3 expression by Ace2 and Ash1 can account for the differential regulation of Start in response to cell size in mothers and daughters.
Title: Daughter-specific transcription factors regulate cell size control in budding yeast.
In the daughter cell nucleus Cbk1p phosphorylates the Ace2p nuclear export signal, and the phosphorylation blocks the export of Ace2p via Crm1p.
Title: Mutations in a small region of the exportin Crm1p disrupt the daughter cell-specific nuclear localization of the transcription factor Ace2p in Saccharomyces cerevisiae.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	HDA more info	PubMed
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of antisense RNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of septum digestion after cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA-binding transcription factor ACE2

NP_013232.1

Transcription factor required for septum destruction after cytokinesis; part of the RAM network that regulates polarity and morphogenesis; NES phosphorylation by RAM network kinase Cbk1p blocks nuclear exit in mother cells during the M/G1 transition, causing asymmetric localization to daughter cell nuclei, and increased Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; Spt16p is required for nuclear exclusion during G1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

404510..406822 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182018.1 → NP_013232.1 TPA: DNA-binding transcription factor ACE2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013232.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYC6, P21192

UniProtKB/TrEMBL

A0A8H4BX45, A7A130, B3LT92, C8ZDA0, G2WIX0, N1NZP7

Conserved Domains (2) summary

COG5048
Location:176 → 683

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:605 → 627

ZF_C2H2; C2H2 Zn finger [structural motif]