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    GPI13 mannose-ethanolamine phosphotransferase GPI13 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850628, updated on 1-Aug-2024

    Summary

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    Gene symbol
    GPI13
    Gene description
    mannose-ethanolamine phosphotransferase GPI13
    Primary source
    FungiDB:YLL031C
    Locus tag
    YLL031C
    See related
    SGD:S000003954; AllianceGenome:SGD:S000003954; VEuPathDB:YLL031C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MPC1
    Summary
    Enables mannose-ethanolamine phosphotransferase activity. Involved in GPI anchor biosynthetic process. Located in endoplasmic reticulum. Orthologous to human PIGO (phosphatidylinositol glycan anchor biosynthesis class O). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GPI13 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (77152..80205, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Irc19p Neighboring gene uncharacterized protein Neighboring gene Rrt7p Neighboring gene aminopeptidase P

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An improved integration replacement/disruption method for mutagenesis of yeast essential genes. Tohe A, et al. Genes Genet Syst, 2000 Feb. PMID 10846619
    2. YLL031c belongs to a novel family of membrane proteins involved in the transfer of ethanolaminephosphate onto the core structure of glycosylphosphatidylinositol anchors in yeast. Flury I, et al. J Biol Chem, 2000 Aug 11. PMID 10823837
    3. Glycosylphosphatidylinositol biosynthesis defects in Gpi11p- and Gpi13p-deficient yeast suggest a branched pathway and implicate gpi13p in phosphoethanolamine transfer to the third mannose. Taron CH, et al. Mol Biol Cell, 2000 May. PMID 10793139, Free PMC Article
    4. Disruption of six novel ORFs on the left arm of chromosome XII reveals one gene essential for vegetative growth of Saccharomyces cerevisiae. Zhang N, et al. Yeast, 1999 Sep 15. PMID 10487931
    5. Glycosylphosphatidylinositol (GPI) proteins of Saccharomyces cerevisiae contain ethanolamine phosphate groups on the alpha1,4-linked mannose of the GPI anchor. Imhof I, et al. J Biol Chem, 2004 May 7. PMID 14985347

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mannose-ethanolamine phosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannose-ethanolamine phosphotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannose-ethanolamine phosphotransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity, transferring phosphorus-containing groups IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GPI anchor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organophosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphate-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mannose-ethanolamine phosphotransferase GPI13
    NP_013069.1
    • ER membrane localized phosphoryltransferase; adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      77152..80205 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181851.1 → NP_013069.1  TPA: mannose-ethanolamine phosphotransferase GPI13 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013069.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXX4, Q07830
      UniProtKB/TrEMBL
      C7GQE2, C8ZCU2, G2WIG5, N1NZH3
      Conserved Domains (2) summary
      COG1524
      Location:48 → 701
      Npp1; Predicted pyrophosphatase or phosphodiesterase, AlkP superfamily [General function prediction only]
      cd16023
      Location:77 → 367
      GPI_EPT_3; GPI ethanolamine phosphate transferase 3, PIG-O
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07830.1

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