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    MRS1 Mrs1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854839, updated on 1-Aug-2024

    Summary

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    Gene symbol
    MRS1
    Gene description
    Mrs1p
    Primary source
    FungiDB:YIR021W
    Locus tag
    YIR021W
    See related
    SGD:S000001460; AllianceGenome:SGD:S000001460; VEuPathDB:YIR021W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PET157
    Summary
    Enables RNA binding activity. Involved in Group I intron splicing and mitochondrial RNA processing. Located in mitochondrion. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MRS1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (397294..398385)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene signal peptidase complex catalytic subunit SEC11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning of a nuclear gene MRS1 involved in the excision of a single group I intron (bI3) from the mitochondrial COB transcript in S. cerevisiae. Kreike J, et al. Curr Genet, 1986. PMID 2834089
    2. A yeast nuclear gene, MRS1, involved in mitochondrial RNA splicing: nucleotide sequence and mutational analysis of two overlapping open reading frames on opposite strands. Kreike J, et al. EMBO J, 1987 Jul. PMID 2443348, Free PMC Article
    3. Multiple molecular mechanisms cause reproductive isolation between three yeast species. Chou JY, et al. PLoS Biol, 2010 Jul 20. PMID 20652018, Free PMC Article
    4. The Mrs1 splicing factor binds the bI3 group I intron at each of two tetraloop-receptor motifs. Duncan CD, et al. PLoS One, 2010 Feb 1. PMID 20126554, Free PMC Article
    5. Kinetic and thermodynamic framework for assembly of the six-component bI3 group I intron ribonucleoprotein catalyst. Bassi GS, et al. Biochemistry, 2003 Aug 26. PMID 12924947

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that Mrs1 binds a ubiquitous RNA tertiary structure motif, the GNRA tetraloop-receptor interaction, at two sites in the bI3 RNA.
      Title: The Mrs1 splicing factor binds the bI3 group I intron at each of two tetraloop-receptor motifs.
    2. defects in Suv3p result in accumulation of stable, excised group I intron ribonucleoproteins, which result in sequestration of Mrs1p, and a concomitant reduction in splicing of aI5beta
      Title: Splicing of yeast aI5beta group I intron requires SUV3 to recycle MRS1 via mitochondrial degradosome-promoted decay of excised intron ribonucleoprotein (RNP).
    3. Data suggest that Mrs1p stabilizes RNA structure and promotes the first step in splicing, while Mss116p acts after the first step and, utilizing ATP hydrolysis, specifically enhances the efficiency of exon ligation.
      Title: A DExH/D-box protein coordinates the two steps of splicing in a group I intron.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Y-form DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables crossed form four-way junction DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flap-structured DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Group I intron splicing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial RNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial genome maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Mrs1p
    NP_012287.3
    • Splicing protein; required for splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA; MRS1 has a paralog, CCE1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      397294..398385
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179543.3 → NP_012287.3  TPA: Mrs1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012287.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVV1, P07266
      UniProtKB/TrEMBL
      A6ZVU0, G2WFU8, N1P0R5
      Conserved Domains (1) summary
      pfam09159
      Location:83 → 357
      Ydc2-catalyt; Mitochondrial resolvase Ydc2 / RNA splicing MRS1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07266.2

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