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    SAP155 Sap155p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850601, updated on 29-Jun-2024

    Summary

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    Gene symbol
    SAP155
    Gene description
    Sap155p
    Primary source
    FungiDB:YFR040W
    Locus tag
    YFR040W
    See related
    SGD:S000001936; AllianceGenome:SGD:S000001936; VEuPathDB:YFR040W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable protein phosphatase regulator activity. Involved in G1/S transition of mitotic cell cycle. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human PPP6R1 (protein phosphatase 6 regulatory subunit 1); PPP6R2 (protein phosphatase 6 regulatory subunit 2); and PPP6R3 (protein phosphatase 6 regulatory subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SAP155 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (234242..237250)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene putative ATPase Neighboring gene Osw7p Neighboring gene Erj5p Neighboring gene Keg1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysis. Wang C, et al. Genes Dev, 1998 May 15. PMID 9585501, Free PMC Article
    2. Sit4p protein phosphatase is required for sensitivity of Saccharomyces cerevisiae to Kluyveromyces lactis zymocin. Jablonowski D, et al. Genetics, 2001 Dec. PMID 11779790, Free PMC Article
    3. TOR controls transcriptional and translational programs via Sap-Sit4 protein phosphatase signaling effectors. Rohde JR, et al. Mol Cell Biol, 2004 Oct. PMID 15367655, Free PMC Article
    4. The SIT4 protein phosphatase functions in late G1 for progression into S phase. Sutton A, et al. Mol Cell Biol, 1991 Apr. PMID 1848673, Free PMC Article
    5. Identification of phosphatase 2A-like Sit4-mediated signalling and ubiquitin-dependent protein sorting as modulators of caffeine sensitivity in S. cerevisiae. Hood-DeGrenier JK. Yeast, 2011 Mar. PMID 21360731

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of potassium ion export across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of potassium ion export across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of phosphoprotein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U2-type spliceosomal complex ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Sap155p
    NP_116698.3
    • Protein required for function of the Sit4p protein phosphatase; forms a complex with Sit4p; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p; protein abundance increases in response to DNA replication stress; SAP155 has a paralog, SAP4, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      234242..237250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180005.2 → NP_116698.3  TPA: Sap155p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116698.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTS3, P43612, Q96VG4
      UniProtKB/TrEMBL
      A0A8H8ULC4, A7A280, G2WDI1, N1P6U9
      Conserved Domains (1) summary
      pfam04499
      Location:334 → 847
      SAPS; SIT4 phosphatase-associated protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43612.4

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