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    PET122 Pet122p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856897, updated on 1-Aug-2024

    Summary

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    Gene symbol
    PET122
    Gene description
    Pet122p
    Primary source
    FungiDB:YER153C
    Locus tag
    YER153C
    See related
    SGD:S000000955; AllianceGenome:SGD:S000000955; VEuPathDB:YER153C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables translation initiation factor activity. Involved in mitochondrial cytochrome c oxidase assembly and positive regulation of mitochondrial translation. Located in mitochondrial inner membrane. Is integral component of mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PET122 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (474041..474805, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene mRNA-binding ubiquitin-specific protease UBP3 Neighboring gene 2-aminoadipate transaminase Neighboring gene membrane insertase OXA1 Neighboring gene GTPase-activating protein BEM2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and nucleotide sequence of the nuclear PET122 gene required for expression of the mitochondrial COX3 gene in S. cerevisiae. Ohmen JD, et al. Nucleic Acids Res, 1988 Nov 25. PMID 2849752, Free PMC Article
    2. Identification of a third nuclear protein-coding gene required specifically for posttranscriptional expression of the mitochondrial COX3 gene is Saccharomyces cerevisiae. Kloeckener-Gruissem B, et al. J Bacteriol, 1988 Mar. PMID 2830240, Free PMC Article
    3. In Saccharomyces cerevisiae, withdrawal of the carbon source results in detachment of glycolytic enzymes from the cytoskeleton and in actin reorganization. Espinoza-Simón E, et al. Fungal Biol, 2020 Jan. PMID 31892373
    4. Expression of the divergent transcription unit containing the yeast PET122 and OXA1 genes. Marathe SV, et al. Biochem Mol Biol Int, 1999 Jun. PMID 10410243
    5. A novel small-subunit ribosomal protein of yeast mitochondria that interacts functionally with an mRNA-specific translational activator. McMullin TW, et al. Mol Cell Biol, 1990 Sep. PMID 2167435, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial cytochrome c oxidase assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitochondrial translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pet122p
    NP_011080.1
    • Mitochondrial translational activator specific for the COX3 mRNA; acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      474041..474805 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179043.1 → NP_011080.1  TPA: Pet122p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011080.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM60, P10355
      UniProtKB/TrEMBL
      A6ZRB0, B3LRR6, C7GQ43, C8Z7H6, G2WD40, N1P3N3
      Conserved Domains (1) summary
      pfam05476
      Location:6 → 248
      PET122
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10355.2

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