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    FTR1 high-affinity iron permease FTR1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856888, updated on 29-Jun-2024

    Summary

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    Gene symbol
    FTR1
    Gene description
    high-affinity iron permease FTR1
    Primary source
    FungiDB:YER145C
    Locus tag
    YER145C
    See related
    SGD:S000000947; AllianceGenome:SGD:S000000947; VEuPathDB:YER145C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables iron ion transmembrane transporter activity. Involved in arsenate ion transmembrane transport and iron ion transmembrane transport. Located in plasma membrane. Part of high-affinity iron permease complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See FTR1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (460526..461740, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Ddi1p Neighboring gene putative ubiquitin-specific protease UBP5 Neighboring gene uncharacterized protein Neighboring gene RNA-binding protein LSM5 Neighboring gene cohesin-loading factor complex subunit SCC4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A ferroxidation/permeation iron uptake system is required for virulence in Ustilago maydis. Eichhorn H, et al. Plant Cell, 2006 Nov. PMID 17138696, Free PMC Article
    2. Cloning and functional characterization of the Rhizopus oryzae high affinity iron permease (rFTR1) gene. Fu Y, et al. FEMS Microbiol Lett, 2004 Jun 1. PMID 15158278
    3. The Ftr1p iron permease in the yeast plasma membrane: orientation, topology and structure-function relationships. Severance S, et al. Biochem J, 2004 Jun 1. PMID 14992688, Free PMC Article
    4. Epigallocatechin-3-O-gallate, the main green tea component, is toxic to Saccharomyces cerevisiae cells lacking the Fet3/Ftr1. Ruta LL, et al. Food Chem, 2018 Nov 15. PMID 30381188
    5. Identification of the molecular mechanisms underlying the cytotoxic action of a potent platinum metallointercalator. Wang S, et al. J Chem Biol, 2012 Apr. PMID 23226166, Free PMC Article

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High-affinity iron and calcium transport pathways are involved in U(VI) uptake in the budding yeast Saccharomyces cerevisiae.
      Title: High-affinity iron and calcium transport pathways are involved in U(VI) uptake in the budding yeast Saccharomyces cerevisiae.
    2. results are consistent with a (minimal) heterodimer model of the Fet3p.Ftr1p complex that supports the trafficking of iron from Fet3p to Ftr1p for iron permeation across the yeast plasma membrane
      Title: Assembly, activation, and trafficking of the Fet3p.Ftr1p high affinity iron permease complex in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ferrous iron transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to iron ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables iron ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables iron ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in arsenate ion transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in iron ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iron ion transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in iron ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of high-affinity iron permease complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of high-affinity iron permease complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of high-affinity iron permease complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    high-affinity iron permease FTR1
    NP_011072.1
    • High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      460526..461740 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179035.1 → NP_011072.1  TPA: high-affinity iron permease FTR1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011072.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM52, P40088
      UniProtKB/TrEMBL
      A0A6A5Q0D6, B3LRQ8, C7GQ51, C8Z7G5, G2WD32, N1PA60
      Conserved Domains (1) summary
      COG0672
      Location:1 → 397
      FTR1; High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40088.1

    Gene LinkOut

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