ATG19 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ATG19
Primary source: SGD:S000005442
Locus tag: YOL082W
See related: AllianceGenome:SGD:S000005442; FungiDB:YOL082W; VEuPathDB:YOL082W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CVT19
Summary: Enables protein-macromolecule adaptor activity. Involved in several processes, including selective autophagy; ubiquitin-dependent ERAD pathway; and vesicle organization. Located in phagophore assembly site. Is extrinsic component of membrane. Part of Cvt complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (168727..169974)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The purified autophagy receptor ATG19 is recruited to affinity resins via a suitable tag and then added to fluorescently labeled ATG8 in solution. The relative strength of the interaction is assessed by determination of the fluorescence intensity on the surface of the bead at an equilibrium binding state. The relative binding strength is determined.
Title: Studies of Receptor-Atg8 Interactions During Selective Autophagy.
one Atg19 molecule has the ability to interact with multiple Atg8 proteins simultaneously, resulting in a high-avidity interaction that may confer specific binding to the Atg8-coated autophagosomal membrane on which Atg8 is concentrated.
Title: Accessory Interaction Motifs in the Atg19 Cargo Receptor Enable Strong Binding to the Clustered Ubiquitin-related Atg8 Protein.
The essential kinase Hrr25 activates the cargo receptor Atg19 by phosphorylation.
Title: Hrr25 kinase promotes selective autophagy by phosphorylating the cargo receptor Atg19.
Cargo binding to Atg19 unmasks additional Atg8 binding sites to mediate membrane-cargo apposition during selective autophagy.
Title: Cargo binding to Atg19 unmasks additional Atg8 binding sites to mediate membrane-cargo apposition during selective autophagy.
Selective transport of alpha-mannosidase by autophagic pathways: structural basis for cargo recognition by Atg19 and Atg34.
Title: Selective transport of alpha-mannosidase by autophagic pathways: structural basis for cargo recognition by Atg19 and Atg34.
Atg8 mutants that were defective in interaction with the prApe1 receptor Atg19 were characterized.
Title: Mutation at the cargo-receptor binding site of Atg8 also affects its general autophagy regulation function.
both ubiquitination and deubiquitination of Atg19p are required for its full function
Title: Atg19p ubiquitination and the cytoplasm to vacuole trafficking pathway in yeast.
Atg19 mediates a dual interaction prApe1-sorting mechanism through independent, instead of sequential, interactions with Atg11 and Atg8.
Title: Atg19 mediates a dual interaction cargo sorting mechanism in selective autophagy.
ATG19 takes part in the cytoplasm to vacuole targeting pathway for an efficient degradation of misfolded Pma1
Title: Efficient degradation of misfolded mutant Pma1 by endoplasmic reticulum-associated degradation requires Atg19 and the Cvt/autophagy pathway.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables protein-macromolecule adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in ERAD pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex localization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein-containing complex localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Cvt complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in phagophore assembly site	IDA Inferred from Direct Assay more info	PubMed
located_in phagophore assembly site membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Atg19p

NP_014559.1

Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles; interaction with Atg19p during the Cvt pathway requires phosphorylation by Hrr25p