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    MID1 Mid1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855425, updated on 1-Aug-2024

    Summary

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    Gene symbol
    MID1
    Gene description
    Mid1p
    Primary source
    FungiDB:YNL291C
    Locus tag
    YNL291C
    See related
    SGD:S000005235; AllianceGenome:SGD:S000005235; VEuPathDB:YNL291C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables stretch-activated, cation-selective, calcium channel activity. Involved in calcium ion transport. Located in endoplasmic reticulum and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MID1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (84169..85815, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Rab GTPase-activating protein MSB3 Neighboring gene pseudouridine synthase PUS4 Neighboring gene replication factor C subunit 3 Neighboring gene Pcl1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of functional domains of Mid1, a stretch-activated channel component, necessary for localization to the plasma membrane and Ca2+ permeation. Ozeki-Miyawaki C, et al. Exp Cell Res, 2005 Nov 15. PMID 16202999
    2. Phe356 in the yeast Ca2+ channel component Mid1 is a key residue for viability after exposure to alpha-factor. Tada T, et al. Biochem Biophys Res Commun, 2004 Jan 16. PMID 14697255
    3. Molecular dissection of the hydrophobic segments H3 and H4 of the yeast Ca2+ channel component Mid1. Tada T, et al. J Biol Chem, 2003 Mar 14. PMID 12514173
    4. Amiodarone induces a caffeine-inhibited, MID1-depedent rise in free cytoplasmic calcium in Saccharomyces cerevisiae. Courchesne WE, et al. Mol Microbiol, 2003 Jan. PMID 12492866
    5. Essential hydrophilic carboxyl-terminal regions including cysteine residues of the yeast stretch-activated calcium-permeable channel Mid1. Maruoka T, et al. J Biol Chem, 2002 Apr 5. PMID 11796727

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High-affinity iron and calcium transport pathways are involved in U(VI) uptake in the budding yeast Saccharomyces cerevisiae.
      Title: High-affinity iron and calcium transport pathways are involved in U(VI) uptake in the budding yeast Saccharomyces cerevisiae.
    2. Therefore, H(+) extrusion by Pma1 may be important for Ca(2+) influx through Cch1/Mid1. These results suggest that Pma1 interacts physically with Cch1/Mid1 Ca(2+) channels to enhance their activity via its H(+) -pumping activity
      Title: Coupling of a voltage-gated Ca(2+) channel homologue with a plasma membrane H(+) -ATPase in yeast.
    3. Cch1 and Mid1 mediate the ethanol-induced Ca2+ flux.
      Title: Ethanol induces calcium influx via the Cch1-Mid1 transporter in Saccharomyces cerevisiae.
    4. Growth of mutants in the Cch1pMid1p channel is markedly hypersensitive to low temperature and to high iron concentration in the medium.
      Title: The Saccharomyces cerevisiae Ca2+ channel Cch1pMid1p is essential for tolerance to cold stress and iron toxicity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables stretch-activated, monoatomic cation-selective, calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mid1p
    NP_014108.1
    • Stretch-activated Ca2+-permeable cation channel; required for Ca2+ influx stimulated by mating pheromones and some abiotic stresses; sensor of compressive mechanical stress; N-glycosylated membrane protein of the ER and plasma membrane; interacts with Cch1p; oligomerizes; is an alpha2/delta-like protein and participates in the generation of stretch-activated Ca2+-permeable cation channel activity when expressed in mammalian cells

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      84169..85815 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183129.1 → NP_014108.1  TPA: Mid1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014108.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0Q2, P41821
      UniProtKB/TrEMBL
      A6ZSI7, B3LPC9, B5VQC6, C7GS54
      Conserved Domains (1) summary
      pfam12929
      Location:99 → 537
      Mid1; Stretch-activated Ca2+-permeable channel component
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41821.1

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