Ptp10D Protein tyrosine phosphatase 10D [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ptp10Dprovided by FlyBase
Official Full Name: Protein tyrosine phosphatase 10Dprovided by FlyBase
Primary source: FLYBASE:FBgn0004370
Locus tag: Dmel_CG1817
See related: AllianceGenome:FB:FBgn0004370
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 10D; CG1817; CT4920; Dmel\CG1817; dptp; DPTP; Dptp10D; DPTP10D; DPTP[[10D]]; Ptp10; ptp10d; ptp10D; Ptp10d; PTP10D; R-PTP 10D; RPTP10d
Summary: Enables transmembrane receptor protein tyrosine phosphatase activity. Involved in several processes, including long-term memory; negative regulation of signal transduction; and nervous system development. Located in apical part of cell and axon. Is expressed in several structures, including embryonic/larval salivary gland; embryonic/larval trachea; neuropil; presumptive embryonic/larval central nervous system; and spermatozoon. Human ortholog(s) of this gene implicated in colorectal cancer and nephrotic syndrome type 6. Orthologous to several human genes including PTPRB (protein tyrosine phosphatase receptor type B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 10D1-10D4; 1-35 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (11622015..11677338)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (11516048..11571371)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

through a genetic screen in Drosophila, we identify the ligand Sas and the receptor-type tyrosine phosphatase PTP10D as the cell-surface ligand-receptor system that drives tumour-suppressive cell competition
Title: The ligand Sas and its receptor PTP10D drive tumour-suppressive cell competition.
The study of this study showed that neuronal Ptp10D restrains signaling by overexpressed glial Sas, which would otherwise produce strong glial and axonal phenotypes.
Title: Interactions between a receptor tyrosine phosphatase and a cell surface ligand regulate axon guidance and glial-neuronal communication.
Described is the crystal structures of Drosophila melanogaster PTP10D in the apo form as well as in a complex with a substrate peptide and an inhibitor.
Title: Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D.
Results describe a unique tracheal tubulogenesis phenotype caused by loss of both Drosophila type III receptor tyrosine phosphatases (RPTPs), Ptp4E and Ptp10D.
Title: Receptor tyrosine phosphatases control tracheal tube geometries through negative regulation of Egfr signaling.
Unlike Ptp10D, Ptp4E appears to be a relatively minor player in the control of axon guidance
Title: Redundancy and compensation in axon guidance: genetic analysis of the Drosophila Ptp10D/Ptp4E receptor tyrosine phosphatase subfamily.
Ptp10D is expressed only on the innermost core fibers during development of the larval mushroom body.
Title: Receptor tyrosine phosphatases regulate birth order-dependent axonal fasciculation and midline repulsion during development of the Drosophila mushroom body.
Our data clearly demonstrate that signaling through PTP10D in mushroom bodies is critical for the formation of long-term memory.
Title: Receptor-like tyrosine phosphatase PTP10D is required for long-term memory in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axon guidance	IPI Inferred from Physical Interaction more info	PubMed
involved_in branching involved in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell signaling via exosome	IDA Inferred from Direct Assay more info	PubMed
involved_in central nervous system development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in open tracheal system development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein tyrosine phosphatase 10D

Names: CG1817-PB; CG1817-PE; CG1817-PF; CG1817-PG; CG1817-PH; CG1817-PI; Ptp10D-PB; Ptp10D-PE; Ptp10D-PF; Ptp10D-PG; Ptp10D-PH; Ptp10D-PI; protein tyrosine phosphatase 10B

NP_001138187.1

EC 3.1.3.-

EC 3.1.3.48

NP_001259453.1

EC 3.1.3.-

EC 3.1.3.48

NP_001259454.1

EC 3.1.3.-

EC 3.1.3.48

NP_727544.2

EC 3.1.3.-

EC 3.1.3.48

NP_996413.2

EC 3.1.3.-

EC 3.1.3.48

NP_996414.2

EC 3.1.3.-

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

11622015..11677338

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_206691.3 → NP_996414.2 protein tyrosine phosphatase 10D, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996414.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V4B4, B7Z142, F0JAM3, M9PEB6, M9PJI5, P35992, Q0KHT5, Q86NN9, Q8IR87, Q9VYW1

Conserved Domains (4) summary

smart00194
Location:1272 → 1525

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:1298 → 1525

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:583 → 671

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:220 → 304

fn3; Fibronectin type III domain
NM_001144715.2 → NP_001138187.1 protein tyrosine phosphatase 10D, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138187.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P35992

Conserved Domains (4) summary

smart00194
Location:1272 → 1525

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:1298 → 1525

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:583 → 671

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:220 → 304

fn3; Fibronectin type III domain
NM_001272525.1 → NP_001259454.1 protein tyrosine phosphatase 10D, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259454.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P35992

Conserved Domains (4) summary

smart00194
Location:1272 → 1525

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:1298 → 1525

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:583 → 671

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:220 → 304

fn3; Fibronectin type III domain
NM_001272524.1 → NP_001259453.1 protein tyrosine phosphatase 10D, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259453.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P35992

Conserved Domains (4) summary

smart00194
Location:1294 → 1547

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:1320 → 1547

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:599 → 687

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:236 → 320

fn3; Fibronectin type III domain
NM_206690.2 → NP_996413.2 protein tyrosine phosphatase 10D, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996413.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V4B4, B7Z142, F0JAM3, M9PEB6, M9PJI5, P35992, Q0KHT5, Q86NN9, Q8IR87, Q9VYW1

Conserved Domains (4) summary

smart00194
Location:1272 → 1525

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:1298 → 1525

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:583 → 671

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:220 → 304

fn3; Fibronectin type III domain
NM_167292.3 → NP_727544.2 protein tyrosine phosphatase 10D, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727544.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P35992

Conserved Domains (4) summary

smart00194
Location:1272 → 1525

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:1298 → 1525

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:583 → 671

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:220 → 304

fn3; Fibronectin type III domain