Gpm6b glycoprotein m6b [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpm6bprovided by MGI
Official Full Name: glycoprotein m6bprovided by MGI
Primary source: MGI:MGI:107672
See related: Ensembl:ENSMUSG00000031342 AllianceGenome:MGI:107672
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: M6B; Gpm6
Summary: Predicted to be a structural constituent of myelin sheath. Involved in negative regulation of protein localization to cell surface and negative regulation of serotonin uptake. Located in membrane raft and plasma membrane. Is expressed in central nervous system; genitourinary system; and retina. Orthologous to human GPM6B (glycoprotein M6B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in frontal lobe adult (RPKM 105.8), cortex adult (RPKM 101.8) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: X F5; X 76.86 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (165021911..165172028)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (166238943..166389033)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A mutant allele of glycoprotein M6-B (Gpm6b) facilitates behavioral flexibility but increases delay discounting.
Title: A mutant allele of glycoprotein M6-B (Gpm6b) facilitates behavioral flexibility but increases delay discounting.
FTO regulates ocular angiogenesis via m(6)A-YTHDF2-dependent mechanism.
Title: FTO regulates ocular angiogenesis via m(6)A-YTHDF2-dependent mechanism.
Findings demonstrate that GPM6B plays a crucial role in SMC differentiation and regulates SMC differentiation through the activation of TGF-beta-Smad2/3 signaling via direct interactions with TbetaRI.
Title: Glycoprotein M6B Interacts with TβRI to Activate TGF-β-Smad2/3 Signaling and Promote Smooth Muscle Cell Differentiation.
Study identified glycoprotein M6B as a Schwann cell microvilli component of peripheral nodes of Ranvier. Study detected Na(+) channel clusters at heminodes without any associated M6B, indicating that it is not required for initial channel clustering; showed that absence of M6B results in progressive appearance of nodal protrusions of the nodal axolemma, that are often accompanied by the presence of enlarged mitochondria.
Title: Glial M6B stabilizes the axonal membrane at peripheral nodes of Ranvier.
The results of this study proposed that M6b proteins are required for proper extension and guidance of callosal axons that follow one of the most complex trajectories in the mammalian nervous system.
Title: Transcallosal Projections Require Glycoprotein M6-Dependent Neurite Growth and Guidance.
M6B is not efficiently sorted into mature myelin, in which it is 200-fold less abundant than proteolipid protein (PLP).
Title: A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:238110

AI593561 (e-PCR)
- UniSTS:166195

Gpm6b (e-PCR), detects polymorphism
- UniSTS:498502

px-70g9 (e-PCR)
- UniSTS:258157

GPM6B (e-PCR)
- UniSTS:506516

px-8c5 (e-PCR)
- UniSTS:258208

RH126813 (e-PCR)
- UniSTS:167633

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables structural constituent of myelin sheath	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
involved_in central nervous system myelination	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular matrix assembly	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein localization to cell surface	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of serotonin uptake	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of serotonin uptake	IDA Inferred from Direct Assay more info	PubMed
involved_in ossification	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone mineralization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of focal adhesion assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in membrane raft	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
is_active_in myelin sheath	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: neuronal membrane glycoprotein M6-b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177955.2 → NP_001171426.1 neuronal membrane glycoprotein M6-b isoform 1

See identical proteins and their annotated locations for NP_001171426.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AL671905

Consensus CDS

CCDS53245.1

UniProtKB/Swiss-Prot

A2AEG4, P35803, Q8R3J6, Q99L14, Q9D4F5, Q9JHG9, Q9JHI1, Q9JHK2, Q9JI62, Q9JI63, Q9JI64, Q9JI65

UniProtKB/TrEMBL

A2AEG6

Related

ENSMUSP00000107848.3, ENSMUST00000112229.9

Conserved Domains (1) summary

pfam01275
Location:62 → 298

Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)
NM_001177956.2 → NP_001171427.1 neuronal membrane glycoprotein M6-b isoform 2

See identical proteins and their annotated locations for NP_001171427.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an additional segment in the 3' region, as compared to variant 1. The resulting isoform (2) is shorter and has a different C-terminus, as compared to isoform 1.

Source sequence(s)

AL671905

Consensus CDS

CCDS53244.1

UniProtKB/Swiss-Prot

A2AEG4, P35803, Q8R3J6, Q99L14, Q9D4F5, Q9JHG9, Q9JHI1, Q9JHK2, Q9JI62, Q9JI63, Q9JI64, Q9JI65

UniProtKB/TrEMBL

A2AEG3

Related

ENSMUSP00000107842.2, ENSMUST00000112223.8

Conserved Domains (1) summary

pfam01275
Location:62 → 298

Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)
NM_001177957.2 → NP_001171428.1 neuronal membrane glycoprotein M6-b isoform 2

See identical proteins and their annotated locations for NP_001171428.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has an additional exon in the 3' region, as compared to variant 1. The resulting isoform (2) is shorter and has a different C-terminus, as compared to isoform 1.

Source sequence(s)

AL671905

Consensus CDS

CCDS53244.1

UniProtKB/Swiss-Prot

A2AEG4, P35803, Q8R3J6, Q99L14, Q9D4F5, Q9JHG9, Q9JHI1, Q9JHK2, Q9JI62, Q9JI63, Q9JI64, Q9JI65

UniProtKB/TrEMBL

A2AEG3

Related

ENSMUSP00000107846.3, ENSMUST00000112227.9

Conserved Domains (1) summary

pfam01275
Location:62 → 298

Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)
NM_001177958.2 → NP_001171429.1 neuronal membrane glycoprotein M6-b isoform 3

See identical proteins and their annotated locations for NP_001171429.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.

Source sequence(s)

AL671905

Consensus CDS

CCDS53247.1

UniProtKB/Swiss-Prot

A2AEG4, P35803, Q8R3J6, Q99L14, Q9D4F5, Q9JHG9, Q9JHI1, Q9JHK2, Q9JI62, Q9JI63, Q9JI64, Q9JI65

UniProtKB/TrEMBL

Q3US81

Related

ENSMUSP00000107847.2, ENSMUST00000112228.8

Conserved Domains (1) summary

pfam01275
Location:22 → 258

Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)
NM_001177959.2 → NP_001171430.1 neuronal membrane glycoprotein M6-b isoform 5

See identical proteins and their annotated locations for NP_001171430.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) lacks an in-frame exon in the 5' region and has an additional segment in the 3' region,, as compared to variant 1. The resulting isoform (5) lacks an internal segment and has a shorter and different C-terminus, as compared to isoform 1.

Source sequence(s)

AL671905

Consensus CDS

CCDS53246.1

UniProtKB/Swiss-Prot

P35803

Related

ENSMUSP00000107843.2, ENSMUST00000112224.8

Conserved Domains (1) summary

pfam01275
Location:22 → 258

Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)
NM_001177960.2 → NP_001171431.1 neuronal membrane glycoprotein M6-b isoform 5

See identical proteins and their annotated locations for NP_001171431.1

Status: VALIDATED

Description

Transcript Variant: This variant (7) lacks an in-frame exon in the 5' region and has an additional exon in the 3' region,, as compared to variant 1. The resulting isoform (5) lacks an internal segment and has a shorter and different C-terminus, as compared to isoform 1.

Source sequence(s)

AL671905

Consensus CDS

CCDS53246.1

UniProtKB/Swiss-Prot

P35803

Related

ENSMUSP00000107845.3, ENSMUST00000112226.3

Conserved Domains (1) summary

pfam01275
Location:22 → 258

Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)
NM_001177961.2 → NP_001171432.1 neuronal membrane glycoprotein M6-b isoform 6

See identical proteins and their annotated locations for NP_001171432.1

Status: VALIDATED

Description

Transcript Variant: This variant (8) has an alternate 5' sequence and an additional segment in the 3' region,, as compared to variant 1. The resulting isoform (6) is shorter and has different N- and C-termini, as compared to isoform 1.

Source sequence(s)

AL671905, AL713990

Consensus CDS

CCDS53243.1

UniProtKB/TrEMBL

Q3V0Z9

Related

ENSMUSP00000107854.2, ENSMUST00000112235.8

Conserved Domains (1) summary

pfam01275
Location:3 → 239

Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)
NM_001177962.2 → NP_001171433.1 neuronal membrane glycoprotein M6-b isoform 6

See identical proteins and their annotated locations for NP_001171433.1

Status: VALIDATED

Description

Transcript Variant: This variant (9) has an alternate 5' sequence and an additional exon in the 3' region,, as compared to variant 1. The resulting isoform (6) is shorter and has different N- and C-termini, as compared to isoform 1.

Source sequence(s)

AL671905, AL713990

Consensus CDS

CCDS53243.1

UniProtKB/TrEMBL

Q3V0Z9

Related

ENSMUSP00000107852.2, ENSMUST00000112233.8

Conserved Domains (1) summary

pfam01275
Location:3 → 239

Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)
NM_001425662.1 → NP_001412591.1 neuronal membrane glycoprotein M6-b isoform 7

Status: VALIDATED

Source sequence(s)

AL671905, AL713990
NM_001425663.1 → NP_001412592.1 neuronal membrane glycoprotein M6-b isoform 8

Status: VALIDATED

Source sequence(s)

AL671905
NM_001425664.1 → NP_001412593.1 neuronal membrane glycoprotein M6-b isoform 9

Status: VALIDATED

Source sequence(s)

AL671905, AL713990
NM_001425665.1 → NP_001412594.1 neuronal membrane glycoprotein M6-b isoform 10

Status: VALIDATED

Source sequence(s)

AL671905
NM_001425666.1 → NP_001412595.1 neuronal membrane glycoprotein M6-b isoform 10

Status: VALIDATED

Source sequence(s)

AL671905, AL713990
NM_023122.4 → NP_075611.1 neuronal membrane glycoprotein M6-b isoform 4

See identical proteins and their annotated locations for NP_075611.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) has an alternate 5' sequence, as compared to variant 1. The resulting isoform (4) is shorter and has a different N-terminus, as compared to isoform 1.

Source sequence(s)

AL671905, AL713990

Consensus CDS

CCDS30526.1

UniProtKB/Swiss-Prot

A2AEG4, P35803, Q8R3J6, Q99L14, Q9D4F5, Q9JHG9, Q9JHI1, Q9JHK2, Q9JI62, Q9JI63, Q9JI64, Q9JI65

Related

ENSMUSP00000060442.8, ENSMUST00000060210.14

Conserved Domains (1) summary

pfam01275
Location:3 → 239

Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

165021911..165172028

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161822.1 → XP_036017715.1 neuronal membrane glycoprotein M6-b isoform X3

UniProtKB/Swiss-Prot

A2AEG4, P35803, Q8R3J6, Q99L14, Q9D4F5, Q9JHG9, Q9JHI1, Q9JHK2, Q9JI62, Q9JI63, Q9JI64, Q9JI65

Conserved Domains (1) summary

pfam01275
Location:43 → 279

Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)
XM_011247784.3 → XP_011246086.1 neuronal membrane glycoprotein M6-b isoform X1

UniProtKB/Swiss-Prot

A2AEG4, P35803, Q8R3J6, Q99L14, Q9D4F5, Q9JHG9, Q9JHI1, Q9JHK2, Q9JI62, Q9JI63, Q9JI64, Q9JI65

Conserved Domains (1) summary

pfam01275
Location:61 → 297

Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)