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    NOL8 nucleolar protein 8 [ Homo sapiens (human) ]

    Gene ID: 55035, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NOL8provided by HGNC
    Official Full Name
    nucleolar protein 8provided by HGNC
    Primary source
    HGNC:HGNC:23387
    See related
    Ensembl:ENSG00000198000 MIM:611534; AllianceGenome:HGNC:23387
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NOP132; C9orf34; bA62C3.3; bA62C3.4
    Summary
    NOL8 binds Ras-related GTP-binding proteins (see MIM 608267) and plays a role in cell growth (Sekiguchi et al., 2004 [PubMed 14660641]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in lymph node (RPKM 8.0), appendix (RPKM 6.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NOL8 in Genome Data Viewer
    Location:
    9q22.31
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (92297358..92325350, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (104463887..104491986, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (95059640..95087632, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268048 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:94976657-94977553 Neighboring gene isoleucyl-tRNA synthetase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95012769-95013269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28593 Neighboring gene microRNA 3651 Neighboring gene small nucleolar RNA, H/ACA box 84 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:95086914-95087802 Neighboring gene phagophore assembly factor 1 pseudogene Neighboring gene centromere protein P Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_109628 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_109638 Neighboring gene osteoglycin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. NOL8, the binding protein for beta-catenin, promoted the growth and migration of prostate cancer cells. Gu S, et al. Chem Biol Interact, 2018 Oct 1. PMID 30125550
    2. Identification of NOL8, a nucleolar protein containing an RNA recognition motif (RRM), which was overexpressed in diffuse-type gastric cancer. Jinawath N, et al. Cancer Sci, 2004 May. PMID 15132771, Free PMC Article
    3. A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D. Sekiguchi T, et al. J Biol Chem, 2004 Feb 27. PMID 14660641
    4. NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47. Sekiguchi T, et al. Nucleic Acids Res, 2006. PMID 16963496, Free PMC Article
    5. Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B. Sekiguchi T, et al. J Biol Chem, 2001 Mar 9. PMID 11073942

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    2. nucleolar protein 132(Nop132) is associated with the GTP form, but not the GDP form, of ras-related GTP binding protein RRAG A, suggesting that RRAG A might regulate Nop132 function
      Title: A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20736, DKFZp686P12242

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein localization to nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to nucleolus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nucleolar protein 8
    Names
    nucleolar protein Nop132

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256394.2 → NP_001243323.1  nucleolar protein 8 isoform b

      See identical proteins and their annotated locations for NP_001243323.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AB105104, BC146810
      Consensus CDS
      CCDS59135.1
      UniProtKB/TrEMBL
      A6H8Z4
      Related
      ENSP00000351723.4, ENST00000358855.8
      Conserved Domains (1) summary
      cl17169
      Location:1 → 20
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_001330722.2 → NP_001317651.1  nucleolar protein 8 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate, in-frame exon in the central coding region compared to variant 1. It encodes isoform c, which is shorter than isoform a.
      Source sequence(s)
      AB105104, AL136097, BM475696, DB227423, DB516208
      Consensus CDS
      CCDS83384.1
      UniProtKB/TrEMBL
      A6H8Z4
      Related
      ENSP00000441300.1, ENST00000535387.5
      Conserved Domains (1) summary
      cd12226
      Location:9 → 88
      RRM_NOL8; RNA recognition motif in nucleolar protein 8 (NOL8) and similar proteins

    3. NM_017948.6 → NP_060418.4  nucleolar protein 8 isoform a

      See identical proteins and their annotated locations for NP_060418.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AB105104, AL136097
      Consensus CDS
      CCDS47993.1
      UniProtKB/Swiss-Prot
      Q5TCC7, Q5TCC8, Q5TCD3, Q5TCD5, Q5TCD6, Q5TCD7, Q76D35, Q76FK4, Q7L3E2, Q9H586, Q9H795, Q9H7W7, Q9H9J6, Q9NWA4, Q9NWM4
      UniProtKB/TrEMBL
      A6H8Z4
      Related
      ENSP00000401177.2, ENST00000442668.7
      Conserved Domains (1) summary
      cd12226
      Location:9 → 88
      RRM_NOL8; RNA recognition motif in nucleolar protein 8 (NOL8) and similar proteins

    RNA

    1. NR_046106.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' region, compared to variant 1. This variant is represented as non-coding because use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB105104, AL136097, BC146810
      Related
      ENST00000544867.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      92297358..92325350 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006717167.4 → XP_006717230.1  nucleolar protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006717230.1

      UniProtKB/Swiss-Prot
      Q5TCC7, Q5TCC8, Q5TCD3, Q5TCD5, Q5TCD6, Q5TCD7, Q76D35, Q76FK4, Q7L3E2, Q9H586, Q9H795, Q9H7W7, Q9H9J6, Q9NWA4, Q9NWM4
      UniProtKB/TrEMBL
      A6H8Z4
      Conserved Domains (1) summary
      cd12226
      Location:9 → 88
      RRM_NOL8; RNA recognition motif in nucleolar protein 8 (NOL8) and similar proteins

    2. XM_011518824.4 → XP_011517126.1  nucleolar protein 8 isoform X2

      See identical proteins and their annotated locations for XP_011517126.1

      UniProtKB/TrEMBL
      A6H8Z4
      Related
      ENSP00000440709.1, ENST00000542053.5
      Conserved Domains (1) summary
      cl17169
      Location:1 → 20
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. XM_024447594.2 → XP_024303362.1  nucleolar protein 8 isoform X2

      UniProtKB/TrEMBL
      A6H8Z4
      Conserved Domains (1) summary
      cl17169
      Location:1 → 20
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. XM_006717166.5 → XP_006717229.1  nucleolar protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006717229.1

      UniProtKB/Swiss-Prot
      Q5TCC7, Q5TCC8, Q5TCD3, Q5TCD5, Q5TCD6, Q5TCD7, Q76D35, Q76FK4, Q7L3E2, Q9H586, Q9H795, Q9H7W7, Q9H9J6, Q9NWA4, Q9NWM4
      UniProtKB/TrEMBL
      A6H8Z4
      Related
      ENSP00000441140.1, ENST00000545558.5
      Conserved Domains (1) summary
      cd12226
      Location:9 → 88
      RRM_NOL8; RNA recognition motif in nucleolar protein 8 (NOL8) and similar proteins

    5. XM_011518827.3 → XP_011517129.1  nucleolar protein 8 isoform X4

      See identical proteins and their annotated locations for XP_011517129.1

      UniProtKB/TrEMBL
      A6H8Z4

    6. XM_047423554.1 → XP_047279510.1  nucleolar protein 8 isoform X3

      UniProtKB/TrEMBL
      F5H101

    7. XM_047423555.1 → XP_047279511.1  nucleolar protein 8 isoform X5

      UniProtKB/TrEMBL
      F8WE42
      Related
      ENSP00000414112.2, ENST00000432670.6

    8. XM_047423556.1 → XP_047279512.1  nucleolar protein 8 isoform X6

      UniProtKB/TrEMBL
      F8WE42

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791788.1 Reference GRCh38.p14 PATCHES

      Range
      132087..160186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333094.1 → XP_054189069.1  nucleolar protein 8 isoform X1

      UniProtKB/Swiss-Prot
      Q5TCC7, Q5TCC8, Q5TCD3, Q5TCD5, Q5TCD6, Q5TCD7, Q76D35, Q76FK4, Q7L3E2, Q9H586, Q9H795, Q9H7W7, Q9H9J6, Q9NWA4, Q9NWM4
      UniProtKB/TrEMBL
      A6H8Z4

    2. XM_054333095.1 → XP_054189070.1  nucleolar protein 8 isoform X1

      UniProtKB/Swiss-Prot
      Q5TCC7, Q5TCC8, Q5TCD3, Q5TCD5, Q5TCD6, Q5TCD7, Q76D35, Q76FK4, Q7L3E2, Q9H586, Q9H795, Q9H7W7, Q9H9J6, Q9NWA4, Q9NWM4
      UniProtKB/TrEMBL
      A6H8Z4

    3. XM_054333096.1 → XP_054189071.1  nucleolar protein 8 isoform X2

      UniProtKB/TrEMBL
      A6H8Z4

    4. XM_054333097.1 → XP_054189072.1  nucleolar protein 8 isoform X2

      UniProtKB/TrEMBL
      A6H8Z4

    5. XM_054333099.1 → XP_054189074.1  nucleolar protein 8 isoform X4

      UniProtKB/TrEMBL
      A6H8Z4

    6. XM_054333098.1 → XP_054189073.1  nucleolar protein 8 isoform X3

      UniProtKB/TrEMBL
      F5H101

    7. XM_054333100.1 → XP_054189075.1  nucleolar protein 8 isoform X5

      UniProtKB/TrEMBL
      F8WE42

    8. XM_054333101.1 → XP_054189076.1  nucleolar protein 8 isoform X6

      UniProtKB/TrEMBL
      F8WE42

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      104463887..104491986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363204.1 → XP_054219179.1  nucleolar protein 8 isoform X1

      UniProtKB/Swiss-Prot
      Q5TCC7, Q5TCC8, Q5TCD3, Q5TCD5, Q5TCD6, Q5TCD7, Q76D35, Q76FK4, Q7L3E2, Q9H586, Q9H795, Q9H7W7, Q9H9J6, Q9NWA4, Q9NWM4
      UniProtKB/TrEMBL
      A6H8Z4

    2. XM_054363205.1 → XP_054219180.1  nucleolar protein 8 isoform X1

      UniProtKB/Swiss-Prot
      Q5TCC7, Q5TCC8, Q5TCD3, Q5TCD5, Q5TCD6, Q5TCD7, Q76D35, Q76FK4, Q7L3E2, Q9H586, Q9H795, Q9H7W7, Q9H9J6, Q9NWA4, Q9NWM4
      UniProtKB/TrEMBL
      A6H8Z4

    3. XM_054363206.1 → XP_054219181.1  nucleolar protein 8 isoform X2

      UniProtKB/TrEMBL
      A6H8Z4

    4. XM_054363207.1 → XP_054219182.1  nucleolar protein 8 isoform X2

      UniProtKB/TrEMBL
      A6H8Z4

    5. XM_054363209.1 → XP_054219184.1  nucleolar protein 8 isoform X4

      UniProtKB/TrEMBL
      A6H8Z4

    6. XM_054363208.1 → XP_054219183.1  nucleolar protein 8 isoform X3

      UniProtKB/TrEMBL
      F5H101

    7. XM_054363210.1 → XP_054219185.1  nucleolar protein 8 isoform X5

      UniProtKB/TrEMBL
      F8WE42

    8. XM_054363211.1 → XP_054219186.1  nucleolar protein 8 isoform X6

      UniProtKB/TrEMBL
      F8WE42
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q76FK4.1 GenPept UniProtKB/Swiss-Prot:Q76FK4

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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