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    SHD Src homology 2 domain containing transforming protein D [ Homo sapiens (human) ]

    Gene ID: 56961, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SHDprovided by HGNC
    Official Full Name
    Src homology 2 domain containing transforming protein Dprovided by HGNC
    Primary source
    HGNC:HGNC:30633
    See related
    Ensembl:ENSG00000105251 MIM:610481; AllianceGenome:HGNC:30633
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable phosphotyrosine residue binding activity. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in brain (RPKM 6.5), heart (RPKM 2.0) and 5 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SHD in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (4279069..4290722)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (4262345..4273993)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4279066..4290719)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13762 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:4230793-4231294 Neighboring gene Epstein-Barr virus induced 3 Neighboring gene MPRA-validated peak3276 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13763 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13764 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:4246137-4246908 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13766 Neighboring gene YJU2 splicing factor homolog Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9883 Neighboring gene transmembrane and immunoglobulin domain containing 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4301847-4302392 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9884 Neighboring gene fibronectin type III and SPRY domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of two novel SH2 domain-containing proteins from a yeast two hybrid screen with the ABL tyrosine kinase. Oda T, et al. Oncogene, 1997 Sep. PMID 9315092
    2. Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome. Leung KK, et al. Mol Cell Proteomics, 2014 Jul. PMID 24728074, Free PMC Article
    3. Comprehensive binary interaction mapping of SH2 domains via fluorescence polarization reveals novel functional diversification of ErbB receptors. Hause RJ Jr, et al. PLoS One, 2012. PMID 22973453, Free PMC Article
    4. Phospho-tyrosine dependent protein-protein interaction network. Grossmann A, et al. Mol Syst Biol, 2015 Mar 26. PMID 25814554, Free PMC Article
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphotyrosine residue binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SH2 domain-containing adapter protein D
    Names
    src homology 2 domain-containing transforming protein D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001372011.1 → NP_001358940.1  SH2 domain-containing adapter protein D

      Status: VALIDATED

      Source sequence(s)
      AC008616, BC007206
      Consensus CDS
      CCDS12125.1
      UniProtKB/Swiss-Prot
      Q96IW2, Q96NC2
      UniProtKB/TrEMBL
      M0QYZ4
      Conserved Domains (1) summary
      cd10390
      Location:238 → 335
      SH2_SHD; Src homology 2 domain found in SH2 domain-containing adapter proteins D (SHD)

    2. NM_020209.4 → NP_064594.3  SH2 domain-containing adapter protein D

      See identical proteins and their annotated locations for NP_064594.3

      Status: VALIDATED

      Source sequence(s)
      AC008616, BC007206
      Consensus CDS
      CCDS12125.1
      UniProtKB/Swiss-Prot
      Q96IW2, Q96NC2
      UniProtKB/TrEMBL
      M0QYZ4
      Related
      ENSP00000446058.1, ENST00000543264.7
      Conserved Domains (1) summary
      cd10390
      Location:238 → 335
      SH2_SHD; Src homology 2 domain found in SH2 domain-containing adapter proteins D (SHD)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      4279069..4290722
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      4262345..4273993
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96IW2.1 GenPept UniProtKB/Swiss-Prot:Q96IW2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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