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    Tspan11 tetraspanin 11 [ Mus musculus (house mouse) ]

    Gene ID: 68498, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Tspan11provided by MGI
    Official Full Name
    tetraspanin 11provided by MGI
    Primary source
    MGI:MGI:1915748
    See related
    Ensembl:ENSMUSG00000030351 AllianceGenome:MGI:1915748
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110014F12Rik
    Summary
    Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; bone; central nervous system; genitourinary system; and skin. Orthologous to human TSPAN11 (tetraspanin 11). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in lung adult (RPKM 12.6), limb E14.5 (RPKM 4.0) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tspan11 in Genome Data Viewer
    Location:
    6 F3; 6 62.56 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (127864585..127930940)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (127887509..127953031)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38901 Neighboring gene predicted gene, 46976 Neighboring gene predicted gene, 40401 Neighboring gene STARR-seq mESC enhancer starr_17424 Neighboring gene predicted gene, 38903 Neighboring gene predicted gene 15870 Neighboring gene tetraspanin 9 Neighboring gene predicted gene, 53341 Neighboring gene predicted gene, 34416

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Unique arrangement of bone matrix orthogonal to osteoblast alignment controlled by Tspan11-mediated focal adhesion assembly. Nakanishi Y, et al. Biomaterials, 2019 Jul. PMID 31030082
    2. Specific tetraspanin functions. Hemler ME. J Cell Biol, 2001 Dec 24. PMID 11756464, Free PMC Article
    3. Appearance of new tetraspanin genes during vertebrate evolution. Garcia-España A, et al. Genomics, 2008 Apr. PMID 18291621
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Unique arrangement of bone matrix orthogonal to osteoblast alignment controlled by Tspan11-mediated focal adhesion assembly.
      Title: Unique arrangement of bone matrix orthogonal to osteoblast alignment controlled by Tspan11-mediated focal adhesion assembly.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin-11
    Names
    tspan-11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026743.3 → NP_081019.1  tetraspanin-11

      See identical proteins and their annotated locations for NP_081019.1

      Status: PROVISIONAL

      Source sequence(s)
      AC145568
      Consensus CDS
      CCDS20567.1
      UniProtKB/Swiss-Prot
      Q9D1D1
      Related
      ENSMUSP00000032501.5, ENSMUST00000032501.6
      Conserved Domains (2) summary
      cd03155
      Location:112 → 220
      CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:16 → 244
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      127864585..127930940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152281.1 → XP_036008174.1  tetraspanin-11 isoform X1

      UniProtKB/Swiss-Prot
      Q9D1D1
      Conserved Domains (2) summary
      cd03155
      Location:112 → 220
      CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:16 → 244
      Tetraspannin; Tetraspanin family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D1D1.1 GenPept UniProtKB/Swiss-Prot:Q9D1D1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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