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    RASGRP2 RAS guanyl releasing protein 2 [ Homo sapiens (human) ]

    Gene ID: 10235, updated on 2-Nov-2024

    Summary

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    Official Symbol
    RASGRP2provided by HGNC
    Official Full Name
    RAS guanyl releasing protein 2provided by HGNC
    Primary source
    HGNC:HGNC:9879
    See related
    Ensembl:ENSG00000068831 MIM:605577; AllianceGenome:HGNC:9879
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDC25L; CALDAG-GEFI
    Summary
    The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
    Expression
    Broad expression in bone marrow (RPKM 28.4), lymph node (RPKM 27.5) and 17 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RASGRP2 in Genome Data Viewer
    Location:
    11q13.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (64726911..64745456, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (64720142..64738685, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64494383..64512928, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 member 12 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64372269-64373070 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64387298-64387914 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64387915-64388530 Neighboring gene neurexin 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4905 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64404690-64405258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64414407-64414908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64414909-64415408 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64415526-64416494 Neighboring gene NRXN2 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64419195-64419694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64421037-64421537 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4906 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64424149-64424650 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64424651-64425150 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:64426961-64428160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64455312-64456232 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4907 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64480596-64481379 Neighboring gene Sharpr-MPRA regulatory region 4107 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3481 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64492769-64493607 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64506559-64507108 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3482 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3483 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3484 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3485 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3486 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3487 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64520964-64521574 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64525447-64526151 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64526152-64526855 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64526856-64527560 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64527561-64528263 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4909 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4910 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64530587-64531460 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64532334-64533208 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64533209-64534081 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64534082-64534955 Neighboring gene glycogen phosphorylase, muscle associated Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4914 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3488 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:64545791-64546392 Neighboring gene splicing factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. RasGRP2 Structure, Function and Genetic Variants in Platelet Pathophysiology. Canault M, et al. Int J Mol Sci, 2020 Feb 6. PMID 32041177, Free PMC Article
    2. Structural Basis for the Failure of the C1 Domain of Ras Guanine Nucleotide Releasing Protein 2 (RasGRP2) to Bind Phorbol Ester with High Affinity. Czikora A, et al. J Biol Chem, 2016 May 20. PMID 27022025, Free PMC Article
    3. Expanded repertoire of RASGRP2 variants responsible for platelet dysfunction and severe bleeding. Westbury SK, et al. Blood, 2017 Aug 24. PMID 28637664, Free PMC Article
    4. Marked bleeding diathesis in patients with platelet dysfunction due to a novel mutation in RASGRP2, encoding CalDAG-GEFI (p.Gly305Asp). Bermejo E, et al. Platelets, 2018 Jan. PMID 28726538, Free PMC Article
    5. Ras guanyl nucleotide releasing protein 2 affects cell viability and cell-matrix adhesion in ECV304 endothelial cells. Takino J, et al. Cell Adh Migr, 2013 May-Jun. PMID 23563504, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NEDD4L-mediated RASGRP2 suppresses high-glucose and oxLDL-induced vascular endothelial cell dysfunctions by activating Rap1 and R-Ras.
      Title: NEDD4L-mediated RASGRP2 suppresses high-glucose and oxLDL-induced vascular endothelial cell dysfunctions by activating Rap1 and R-Ras.
    2. [Study on the Role of RASGRP2 in Vascular Endothelial Cells].
      Title: [Study on the Role of RASGRP2 in Vascular Endothelial Cells].
    3. RASGRP2 is a potential immune-related biomarker and regulates mitochondrial-dependent apoptosis in lung adenocarcinoma.
      Title: RASGRP2 is a potential immune-related biomarker and regulates mitochondrial-dependent apoptosis in lung adenocarcinoma.
    4. Novel RASGRP2 variants in platelet function defects: Indian study.
      Title: Novel RASGRP2 variants in platelet function defects: Indian study.
    5. CalDAG-GEFI Deficiency in a Family with Symptomatic Heterozygous and Homozygous Carriers of a Likely Pathogenic Variant in RASGRP2.
      Title: CalDAG-GEFI Deficiency in a Family with Symptomatic Heterozygous and Homozygous Carriers of a Likely Pathogenic Variant in RASGRP2.
    6. The Role of RASGRP2 in Vascular Endothelial Cells-A Mini Review.
      Title: The Role of RASGRP2 in Vascular Endothelial Cells-A Mini Review.
    7. RasGRP2 inhibits glyceraldehyde-derived toxic advanced glycation end-products from inducing permeability in vascular endothelial cells.
      Title: RasGRP2 inhibits glyceraldehyde-derived toxic advanced glycation end-products from inducing permeability in vascular endothelial cells.
    8. Mutations in RASGRP2 gene identified in patients misdiagnosed as Glanzmann thrombasthenia patients.
      Title: Mutations in RASGRP2 gene identified in patients misdiagnosed as Glanzmann thrombasthenia patients.
    9. A novel missense variant in the RASGRP2 gene in patients with moderate to severe bleeding disorder.
      Title: A novel missense variant in the RASGRP2 gene in patients with moderate to severe bleeding disorder.
    10. RasGRP2 Structure, Function and Genetic Variants in Platelet Pathophysiology.
      Title: RasGRP2 Structure, Function and Genetic Variants in Platelet Pathophysiology.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Platelet-type bleeding disorder 18
    MedGen: C4014584 OMIM: 615888 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables calcium ion binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables diacylglycerol binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables lipid binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Ras protein signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cellular response to calcium ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell growth NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RAS guanyl-releasing protein 2
    Names
    F25B3.3 kinase-like protein
    RAS guanyl nucleotide-releasing protein 2
    RAS guanyl releasing protein 2 (calcium and DAG-regulated)
    calcium and DAG-regulated guanine nucleotide exchange factor I
    calcium and diacylglycerol-regulated guanine nucleotide exchange factor I
    cdc25-like protein
    guanine exchange factor MCG7

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007574.1 RefSeqGene

      Range
      5001..23546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_100

    mRNA and Protein(s)

    1. NM_001098670.2 → NP_001092140.1  RAS guanyl-releasing protein 2 isoform a

      See identical proteins and their annotated locations for NP_001092140.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 2. Variants 2, 3, and 4 all encode the same protein.
      Source sequence(s)
      AF043723, DB498812
      Consensus CDS
      CCDS31598.1
      UniProtKB/Swiss-Prot
      A6NDC7, O00538, Q7LDG7, Q9UL65
      UniProtKB/TrEMBL
      B2RBF2
      Related
      ENSP00000366717.3, ENST00000377497.7
      Conserved Domains (4) summary
      smart00147
      Location:150 → 387
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:7 → 121
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00051
      Location:430 → 481
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd20861
      Location:496 → 551
      C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

    2. NM_001098671.2 → NP_001092141.1  RAS guanyl-releasing protein 2 isoform a

      See identical proteins and their annotated locations for NP_001092141.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 2. Variants 2, 3, and 4 all encode the same protein.
      Source sequence(s)
      AF043723, DA286186
      Consensus CDS
      CCDS31598.1
      UniProtKB/Swiss-Prot
      A6NDC7, O00538, Q7LDG7, Q9UL65
      UniProtKB/TrEMBL
      B2RBF2
      Related
      ENSP00000377953.3, ENST00000394432.8
      Conserved Domains (4) summary
      smart00147
      Location:150 → 387
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:7 → 121
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00051
      Location:430 → 481
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd20861
      Location:496 → 551
      C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

    3. NM_001318398.2 → NP_001305327.1  RAS guanyl-releasing protein 2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate splice junction in the 5' end compared to variant 2. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AF081194, AK122694, DA529151
      UniProtKB/TrEMBL
      B3KV60
      Conserved Domains (4) summary
      smart00147
      Location:5 → 242
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:354 → 403
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:285 → 336
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:286 → 339
      EF-hand_7; EF-hand domain pair

    4. NM_153819.1 → NP_722541.1  RAS guanyl-releasing protein 2 isoform a

      See identical proteins and their annotated locations for NP_722541.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longer isoform (a). Variants 2, 3, and 4 all encode the same isoform (a).
      Source sequence(s)
      AF043723
      Consensus CDS
      CCDS31598.1
      UniProtKB/Swiss-Prot
      A6NDC7, O00538, Q7LDG7, Q9UL65
      UniProtKB/TrEMBL
      B2RBF2
      Related
      ENSP00000338864.3, ENST00000354024.7
      Conserved Domains (4) summary
      smart00147
      Location:150 → 387
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:7 → 121
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00051
      Location:430 → 481
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd20861
      Location:496 → 551
      C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      64726911..64745456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017082.3 → XP_016872571.2  RAS guanyl-releasing protein 2 isoform X3

    2. XM_047426232.1 → XP_047282188.1  RAS guanyl-releasing protein 2 isoform X5

    3. XM_011544723.4 → XP_011543025.1  RAS guanyl-releasing protein 2 isoform X2

      See identical proteins and their annotated locations for XP_011543025.1

      UniProtKB/TrEMBL
      B2RBF2
      Conserved Domains (5) summary
      smart00147
      Location:150 → 387
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:7 → 121
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00029
      Location:499 → 548
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:430 → 481
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:431 → 484
      EF-hand_7; EF-hand domain pair

    4. XM_047426231.1 → XP_047282187.1  RAS guanyl-releasing protein 2 isoform X4

    5. XM_011544721.2 → XP_011543023.1  RAS guanyl-releasing protein 2 isoform X2

      See identical proteins and their annotated locations for XP_011543023.1

      UniProtKB/TrEMBL
      B2RBF2
      Related
      ENSP00000366714.1, ENST00000377494.5
      Conserved Domains (5) summary
      smart00147
      Location:150 → 387
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:7 → 121
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00029
      Location:499 → 548
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:430 → 481
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:431 → 484
      EF-hand_7; EF-hand domain pair

    6. XM_011544718.3 → XP_011543020.1  RAS guanyl-releasing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011543020.1

      Conserved Domains (5) summary
      cd06224
      Location:157 → 228
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:255 → 492
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:604 → 653
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:535 → 586
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:536 → 589
      EF-hand_7; EF-hand domain pair

    7. XM_011544720.3 → XP_011543022.1  RAS guanyl-releasing protein 2 isoform X2

      See identical proteins and their annotated locations for XP_011543022.1

      UniProtKB/TrEMBL
      B2RBF2
      Conserved Domains (5) summary
      smart00147
      Location:150 → 387
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:7 → 121
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00029
      Location:499 → 548
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:430 → 481
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:431 → 484
      EF-hand_7; EF-hand domain pair

    8. XM_047426233.1 → XP_047282189.1  RAS guanyl-releasing protein 2 isoform X6

    9. XM_011544725.3 → XP_011543027.1  RAS guanyl-releasing protein 2 isoform X5

      UniProtKB/TrEMBL
      B3KV60
      Conserved Domains (4) summary
      smart00147
      Location:5 → 242
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:354 → 403
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:285 → 336
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:286 → 339
      EF-hand_7; EF-hand domain pair

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      64720142..64738685 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367437.1 → XP_054223412.1  RAS guanyl-releasing protein 2 isoform X3

    2. XM_054367436.1 → XP_054223411.1  RAS guanyl-releasing protein 2 isoform X2

    3. XM_054367435.1 → XP_054223410.1  RAS guanyl-releasing protein 2 isoform X2

    4. XM_054367433.1 → XP_054223408.1  RAS guanyl-releasing protein 2 isoform X1

    5. XM_054367434.1 → XP_054223409.1  RAS guanyl-releasing protein 2 isoform X2

    6. XM_054367439.1 → XP_054223414.1  RAS guanyl-releasing protein 2 isoform X6

    7. XM_054367438.1 → XP_054223413.1  RAS guanyl-releasing protein 2 isoform X5

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_005825.2: Suppressed sequence

      Description
      NM_005825.2: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7LDG7.1 GenPept UniProtKB/Swiss-Prot:Q7LDG7

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