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    FGL2 fibrinogen like 2 [ Homo sapiens (human) ]

    Gene ID: 10875, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FGL2provided by HGNC
    Official Full Name
    fibrinogen like 2provided by HGNC
    Primary source
    HGNC:HGNC:3696
    See related
    Ensembl:ENSG00000127951 MIM:605351; AllianceGenome:HGNC:3696
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    T49; pT49
    Summary
    The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in spleen (RPKM 83.3), appendix (RPKM 61.0) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FGL2 in Genome Data Viewer
    Location:
    7q11.23
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (77193369..77199819, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (78444483..78450933, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (76822686..76829136, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 185, member A pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:76750721-76751222 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:76751223-76751722 Neighboring gene uncharacterized LOC124901678 Neighboring gene ribosomal protein L7a pseudogene 43 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26203 Neighboring gene coiled-coil domain containing 146 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18318 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26204 Neighboring gene uncharacterized LOC105375359 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18319 Neighboring gene uncharacterized LOC102723791 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:76900911-76901093

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Increased activity of cell membrane-associated prothrombinase, fibrinogen-like protein 2, in peripheral blood mononuclear cells of B-cell lymphoma patients. Rabizadeh E, et al. PLoS One, 2014. PMID 25303152, Free PMC Article
    2. [THE EFFECT OF INFECTIOUS AND AUTOIMMUNE DISEASES ON PROCOAGULANT ACTIVITY OF FIBRINOGEN-LIKE PROTEIN 2 IN THE PERIPHERAL BLOOD]. Cherny I, et al. Harefuah, 2019 Mar. PMID 30916506
    3. Serum soluble fibrinogen-like protein 2 concentration predicts delirium after acute pancreatitis. Xu WB, et al. Brain Behav, 2019 Apr. PMID 30884164, Free PMC Article
    4. The relationship between serum fibrinogen-like protein 2 concentrations and 30-day mortality of patients with traumatic brain injury. Chen TJ, et al. Clin Chim Acta, 2019 Feb. PMID 30503273
    5. The Role of Fibrinogen-Like Protein 2 on Immunosuppression and Malignant Progression in Glioma. Latha K, et al. J Natl Cancer Inst, 2019 Mar 1. PMID 29947810, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CD8[+] T cell-derived Fgl2 regulates immunity in a cell-autonomous manner via ligation of FcgammaRIIB.
      Title: CD8(+) T cell-derived Fgl2 regulates immunity in a cell-autonomous manner via ligation of FcγRIIB.
    2. Presence and activity of Fibrinogen like protein 2 in platelets.
      Title: Presence and activity of Fibrinogen like protein 2 in platelets.
    3. A homozygous truncating mutation of FGL2 is associated with immune dysregulation.
      Title: A homozygous truncating mutation of FGL2 is associated with immune dysregulation.
    4. Assessment of Fibrinogen-like 2 (FGL2) in Human Chronic Kidney Disease through Transcriptomics Data Analysis.
      Title: Assessment of Fibrinogen-like 2 (FGL2) in Human Chronic Kidney Disease through Transcriptomics Data Analysis.
    5. Fibrinogen-like protein 2 in gastrointestinal stromal tumour.
      Title: Fibrinogen-like protein 2 in gastrointestinal stromal tumour.
    6. Soluble fibrinogenlike protein 2 levels are decreased in patients with ischemic heart failure and associated with cardiac function.
      Title: Soluble fibrinogen‑like protein 2 levels are decreased in patients with ischemic heart failure and associated with cardiac function.
    7. Predictive value of soluble fibrinogen-like protein 2 for survival in traumatic patients with sepsis.
      Title: Predictive value of soluble fibrinogen-like protein 2 for survival in traumatic patients with sepsis.
    8. Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu.
      Title: Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu.
    9. Dabigatran activates inflammation resolution by promoting fibrinogen-like protein 2 shedding and RvD5n-3 DPA production.
      Title: Dabigatran activates inflammation resolution by promoting fibrinogen-like protein 2 shedding and RvD5(n-3 DPA) production.
    10. Soluble fibrinogen-like protein 2 in condyloma acuminatum lesions.
      Title: Soluble fibrinogen-like protein 2 in condyloma acuminatum lesions.
    Submit: New GeneRIF Correction See all GeneRIFs (50)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of fibrinogen-like 2 (FGL2) in peptide-treated PBMCs PubMed
    Tat tat HIV-1 Tat downregulates the expression of fibrinogen-like 2 (FGL2) in human primary T cells PubMed
    Vif vif HIV-1 Vif downregulates the expression of fibrinogen-like 2 (FGL2) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of dendritic cell antigen processing and presentation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of macrophage antigen processing and presentation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of memory T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of fibrinogen complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    fibroleukin
    Names
    fibrinogen-like protein 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006682.3 → NP_006673.1  fibroleukin precursor

      See identical proteins and their annotated locations for NP_006673.1

      Status: REVIEWED

      Source sequence(s)
      AC007000, BC033820
      Consensus CDS
      CCDS5591.1
      UniProtKB/Swiss-Prot
      Q14314
      UniProtKB/TrEMBL
      A4D1B8, Q53GD2
      Related
      ENSP00000248598.5, ENST00000248598.6
      Conserved Domains (2) summary
      cl00085
      Location:209 → 435
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      cl27170
      Location:28 → 161
      DUF460; Protein of unknown function (DUF460)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      77193369..77199819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      78444483..78450933 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14314.1 GenPept UniProtKB/Swiss-Prot:Q14314

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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