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    [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856728, updated on 22-Aug-2024

    Summary

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    Primary source
    FungiDB:YER010C
    Locus tag
    YER010C
    See related
    SGD:S000000812; AllianceGenome:SGD:S000000812; VEuPathDB:YER010C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity and oxaloacetate decarboxylase activity. Involved in 3,4-dihydroxybenzoate catabolic process. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (172634..173338, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene GTP-Rho binding exocyst subunit SEC3 Neighboring gene Ran GTPase-binding protein NTF2 Neighboring gene GPI-anchored mannoprotein Neighboring gene tRNA-Glu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of yeast YER010Cp, a knotable member of the RraA protein family. Leulliot N, et al. Protein Sci, 2005 Oct. PMID 16195557, Free PMC Article
    2. Biochemical and structural analysis of RraA proteins to decipher their relationships with 4-hydroxy-4-methyl-2-oxoglutarate/4-carboxy-4-hydroxy-2-oxoadipate aldolases. Mazurkewich S, et al. Biochemistry, 2014 Jan 28. PMID 24359411
    3. Lifespan Control by Redox-Dependent Recruitment of Chaperones to Misfolded Proteins. Hanzén S, et al. Cell, 2016 Jun 30. PMID 27264606
    4. The nucleotide sequence of Saccharomyces cerevisiae chromosome V. Dietrich FS, et al. Nature, 1997 May 29. PMID 9169868, Free PMC Article
    5. Functional characterisation of long intergenic non-coding RNAs through genetic interaction profiling in Saccharomyces cerevisiae. Kyriakou D, et al. BMC Biol, 2016 Dec 7. PMID 27927215, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxaloacetate decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxaloacetate decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxaloacetate decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3,4-dihydroxybenzoate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    bifunctional 4-hydroxy-4-methyl-2-oxoglutarate aldolase/oxaloacetate decarboxylase
    NP_010926.3
    • Bifunctional HMG aldolase/oxaloacetate decarboxylase; requires divalent metal ions for activity; competitively inhibited by oxalate; forms a ring-shaped homotrimer; similar to members of the prokaryotic RraA family of class II (divalent metal ion dependent) pyruvate aldolases from the meta cleavage pathways of protocatechuate and gallate

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      172634..173338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178901.3 → NP_010926.3  TPA: bifunctional 4-hydroxy-4-methyl-2-oxoglutarate aldolase/oxaloacetate decarboxylase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010926.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLQ7, P40011
      UniProtKB/TrEMBL
      B3LS22, B5VHE0, C8Z710, G2WCP1, N1P3X5
      Conserved Domains (1) summary
      COG0684
      Location:2 → 231
      RraA; Regulator of RNase E activity RraA [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40011.1

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