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    IL17D interleukin 17D [ Homo sapiens (human) ]

    Gene ID: 53342, updated on 28-Oct-2024

    Summary

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    Official Symbol
    IL17Dprovided by HGNC
    Official Full Name
    interleukin 17Dprovided by HGNC
    Primary source
    HGNC:HGNC:5984
    See related
    Ensembl:ENSG00000172458 MIM:607587; AllianceGenome:HGNC:5984
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IL-17D
    Summary
    The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. The treatment of endothelial cells with this cytokine has been shown to stimulate the production of other cytokines including IL6, IL8 and CSF2/ GM-CSF. The increased expression of IL8 induced by this cytokine was found to be NF-kappa B-dependent. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 13.7), ovary (RPKM 2.3) and 11 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See IL17D in Genome Data Viewer
    Location:
    13q12.11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (20701513..20723098)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (19894661..19916241)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (21275652..21297237)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 88 Neighboring gene solute carrier family 35 member E1 pseudogene 1 Neighboring gene RNA, U2 small nuclear 7, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5155 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5156 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5157 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:21290864-21291578 Neighboring gene Sharpr-MPRA regulatory region 1468 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21303728-21304255 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21304256-21304782 Neighboring gene EEF1A lysine methyltransferase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7426 Neighboring gene RAN pseudogene 8 Neighboring gene exportin 4 Neighboring gene uncharacterized LOC124903129

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Interleukin-17D promotes lung cancer progression by inducing tumor-associated macrophage infiltration via the p38 MAPK signaling pathway. Lin Z, et al. Aging (Albany NY), 2022 Aug 5. PMID 35939336, Free PMC Article
    2. Nuclear factor erythroid 2-related factor 2 potentiates the generation of inflammatory cytokines by intestinal epithelial cells during hyperoxia by inducing the expression of interleukin 17D. Liu X, et al. Toxicology, 2021 Jun 15. PMID 34023435
    3. Interleukin-17D mediates tumor rejection through recruitment of natural killer cells. O'Sullivan T, et al. Cell Rep, 2014 May 22. PMID 24794441, Free PMC Article
    4. Interleukin-17D produced by alveolar epithelial type II cells alleviates LPS-induced acute lung injury via the Nrf2 pathway. Dong S, et al. Clin Sci (Lond), 2023 Sep 27. PMID 37708335
    5. Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis. Starnes T, et al. J Immunol, 2002 Jul 15. PMID 12097364

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interleukin-17D produced by alveolar epithelial type II cells alleviates LPS-induced acute lung injury via the Nrf2 pathway.
      Title: Interleukin-17D produced by alveolar epithelial type II cells alleviates LPS-induced acute lung injury via the Nrf2 pathway.
    2. Interleukin-17D promotes lung cancer progression by inducing tumor-associated macrophage infiltration via the p38 MAPK signaling pathway.
      Title: Interleukin-17D promotes lung cancer progression by inducing tumor-associated macrophage infiltration via the p38 MAPK signaling pathway.
    3. Nuclear factor erythroid 2-related factor 2 potentiates the generation of inflammatory cytokines by intestinal epithelial cells during hyperoxia by inducing the expression of interleukin 17D.
      Title: Nuclear factor erythroid 2-related factor 2 potentiates the generation of inflammatory cytokines by intestinal epithelial cells during hyperoxia by inducing the expression of interleukin 17D.
    4. Nrf2 Induces IL-17D to mediate tumor and virus surveillance.
      Title: Nrf2 Induces IL-17D to Mediate Tumor and Virus Surveillance.
    5. Study of the expression of IL-17 provides theoretical support for the clinical treatment and prognosis prediction of ovarian epithelial tumor.
      Title: Expression of inflammatory cytokines in ovarian epithelial cancer and their correlation.
    6. Utilizing gene microarray analysis, authors found the cytokine interleukin 17D (IL-17D) was highly expressed in certain unedited tumors.
      Title: Interleukin-17D mediates tumor rejection through recruitment of natural killer cells.
    7. These experiments were designed to investigate the effects of IL-17 upon the phenotype and function of human Natural Killer (NK) cells.
      Title: The effects of IL-17 upon human natural killer cells.
    8. IL-27 priming results in enhanced lipopolysaccharide-induced IL-6, tumor necrosis factor (TNF)-alpha, macrophage inflammatory protein (MIP)-1alpha, and MIP-1beta expression in human primary monocytes.
      Title: IL-27 enhances LPS-induced proinflammatory cytokine production via upregulation of TLR4 expression and signaling in human monocytes.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: New genetic associations detected in a host response study to hepatitis B vaccine.
    10. IL-17D stimulates production of cytokines in endothelial cells in vitro and suppresses proliferation of myeloid progenitors in colony formation assays.
      Title: Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic determinants of P wave duration and PR segment.
    EBI GWAS Catalog
    GWAS of dental caries patterns in the permanent dentition.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ30846

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables receptor ligand activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in inflammatory response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of hemopoiesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cytokine production involved in inflammatory response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of granulocyte macrophage colony-stimulating factor production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of interleukin-8 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interleukin-17D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001385221.1 → NP_001372150.1  interleukin-17D isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Isoforms a and b are the same length but differ in their N-termini.
      Source sequence(s)
      AL161772, AL512652
      Conserved Domains (1) summary
      pfam06083
      Location:96 → 177
      IL17; Interleukin-17

    2. NM_001385222.1 → NP_001372151.1  interleukin-17D isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (b). Isoforms a and b are the same length but differ in their N-termini.
      Source sequence(s)
      AL161772, AL512652
      Conserved Domains (1) summary
      pfam06083
      Location:96 → 177
      IL17; Interleukin-17

    3. NM_001385223.1 → NP_001372152.1  interleukin-17D isoform c precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 3 and 5, encodes isoform c.
      Source sequence(s)
      AL161772, AL512652
      Consensus CDS
      CCDS9292.1
      UniProtKB/Swiss-Prot
      B1AM69, Q8TAD2
      Conserved Domains (1) summary
      pfam06083
      Location:89 → 170
      IL17; Interleukin-17

    4. NM_001385224.1 → NP_001372153.1  interleukin-17D isoform c precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 3 and 4, encodes isoform c.
      Source sequence(s)
      AL161772, AL512652
      Consensus CDS
      CCDS9292.1
      UniProtKB/Swiss-Prot
      B1AM69, Q8TAD2
      Related
      ENSP00000508385.1, ENST00000682841.1
      Conserved Domains (1) summary
      pfam06083
      Location:89 → 170
      IL17; Interleukin-17

    5. NM_001385225.1 → NP_001372154.1  interleukin-17D isoform d

      Status: REVIEWED

      Source sequence(s)
      AL161772, AL512652
      Conserved Domains (1) summary
      pfam06083
      Location:11 → 86
      IL17; Interleukin-17

    6. NM_001386973.1 → NP_001373902.1  interleukin-17D isoform e

      Status: REVIEWED

      Source sequence(s)
      AL512652
      Conserved Domains (1) summary
      pfam06083
      Location:9 → 82
      IL17; Interleukin-17

    7. NM_138284.2 → NP_612141.1  interleukin-17D isoform c precursor

      See identical proteins and their annotated locations for NP_612141.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variants 4 and 5, encodes isoform c.
      Source sequence(s)
      AL161772, AL512652
      Consensus CDS
      CCDS9292.1
      UniProtKB/Swiss-Prot
      B1AM69, Q8TAD2
      Related
      ENSP00000302924.3, ENST00000304920.3
      Conserved Domains (1) summary
      pfam06083
      Location:89 → 170
      IL17; Interleukin-17

    RNA

    1. NR_169590.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL161772, AL512652

    2. NR_169591.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL161772, AL512652

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      20701513..20723098
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      19894661..19916241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TAD2.1 GenPept UniProtKB/Swiss-Prot:Q8TAD2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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