U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    RPL31 ribosomal protein L31 [ Homo sapiens (human) ]

    Gene ID: 6160, updated on 28-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    RPL31provided by HGNC
    Official Full Name
    ribosomal protein L31provided by HGNC
    Primary source
    HGNC:HGNC:10334
    See related
    Ensembl:ENSG00000071082 MIM:617415; AllianceGenome:HGNC:10334
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L31; eL31
    Summary
    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L31E family of ribosomal proteins. It is located in the cytoplasm. Higher levels of expression of this gene in familial adenomatous polyps compared to matched normal tissues have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 450.2), bone marrow (RPKM 284.8) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See RPL31 in Genome Data Viewer
    Location:
    2q11.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (101002289..101019724)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (101460986..101478421)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (101618751..101636186)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373508 Neighboring gene neuronal PAS domain protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:101504140-101504909 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:101518843-101520042 Neighboring gene Sharpr-MPRA regulatory region 12407 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16295 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:101599407-101599908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:101599909-101600408 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:101601340-101601535 Neighboring gene NPAS2 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:101607367-101608009 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:101611812-101612312 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16296 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:101619087-101619741 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:101621211-101621711 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16297 Neighboring gene ubiquitin specific peptidase 15 pseudogene Neighboring gene uncharacterized LOC105373510 Neighboring gene TBC1 domain family member 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:101661499-101662000 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:101663058-101663602 Neighboring gene BBSome interacting protein 1 pseudogene 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification of a human ribosomal protein mRNA with increased expression in colorectal tumours. Chester KA, et al. Biochim Biophys Acta, 1989 Dec 22. PMID 2597680
    2. cDNA sequence of human ribosomal protein L31. Nobori T, et al. Nucleic Acids Res, 1989 Sep 12. PMID 2780320, Free PMC Article
    3. Exploiting pre-rRNA processing in Diamond Blackfan anemia gene discovery and diagnosis. Farrar JE, et al. Am J Hematol, 2014 Oct. PMID 25042156, Free PMC Article
    4. Silencing eL31 suppresses the progression of colorectal cancer via targeting DEPDC1. Sharen G, et al. J Transl Med, 2022 Oct 29. PMID 36309731, Free PMC Article
    5. Short hairpin RNA library-based functional screening identified ribosomal protein L31 that modulates prostate cancer cell growth via p53 pathway. Maruyama Y, et al. PLoS One, 2014. PMID 25285958, Free PMC Article

    See all (211) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Silencing eL31 suppresses the progression of colorectal cancer via targeting DEPDC1.
      Title: Silencing eL31 suppresses the progression of colorectal cancer via targeting DEPDC1.
    2. protein levels of the tumor suppressor p53 and its targets, p21 and MDM2, were increased in LNCaP and bicalutamide-resistant LNCaP cells treated with RPL31 siRNA.
      Title: Short hairpin RNA library-based functional screening identified ribosomal protein L31 that modulates prostate cancer cell growth via p53 pathway.
    3. gene discovery in DBA, resulting in the identification of RPL31 as a novel DBA gene.
      Title: Exploiting pre-rRNA processing in Diamond Blackfan anemia gene discovery and diagnosis.
    Submit: New GeneRIF Correction

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC88191

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in cytoplasmic translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of cytosolic large ribosomal subunit HDA PubMed 
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in focal adhesion HDA PubMed 
    located_in membrane HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    large ribosomal subunit protein eL31
    Names
    60S ribosomal protein L31

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000993.5 → NP_000984.1  large ribosomal subunit protein eL31 isoform 1

      See identical proteins and their annotated locations for NP_000984.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.
      Source sequence(s)
      AC016738, BC017343, BC070373, DA869102
      Consensus CDS
      CCDS2049.1
      UniProtKB/Swiss-Prot
      B7Z4K2, D3DVJ4, P12947, P62899, Q53SQ5, Q6IRZ0, Q6LBJ6
      UniProtKB/TrEMBL
      B2R4C1
      Related
      ENSP00000264258.3, ENST00000264258.8
      Conserved Domains (1) summary
      pfam01198
      Location:19 → 100
      Ribosomal_L31e; Ribosomal protein L31e

    2. NM_001098577.3 → NP_001092047.1  large ribosomal subunit protein eL31 isoform 2

      See identical proteins and their annotated locations for NP_001092047.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate terminal exon; the resulting isoform (2) has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC016738, BE564858, CN269912, CN269915, DA869102
      Consensus CDS
      CCDS46373.1
      UniProtKB/TrEMBL
      C9JU56
      Related
      ENSP00000386717.3, ENST00000409028.8
      Conserved Domains (1) summary
      pfam01198
      Location:19 → 100
      Ribosomal_L31e; Ribosomal protein L31e

    3. NM_001099693.2 → NP_001093163.1  large ribosomal subunit protein eL31 isoform 3

      See identical proteins and their annotated locations for NP_001093163.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an unspliced 3' sequence compared to variant 1; the resulting isoform (3) has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC070210, DA869102
      Consensus CDS
      CCDS46374.1
      UniProtKB/TrEMBL
      C9JU56
      Related
      ENSP00000387163.3, ENST00000409320.7
      Conserved Domains (1) summary
      pfam01198
      Location:19 → 100
      Ribosomal_L31e; Ribosomal protein L31e

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      101002289..101019724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      101460986..101478421
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62899.1 GenPept UniProtKB/Swiss-Prot:P62899

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous