U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    TANGO6 transport and golgi organization 6 homolog [ Homo sapiens (human) ]

    Gene ID: 79613, updated on 3-Nov-2024

    Summary

    Official Symbol
    TANGO6provided by HGNC
    Official Full Name
    transport and golgi organization 6 homologprovided by HGNC
    Primary source
    HGNC:HGNC:25749
    See related
    Ensembl:ENSG00000103047 MIM:620188; AllianceGenome:HGNC:25749
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TMCO7
    Summary
    Predicted to be involved in protein secretion. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 3.5), liver (RPKM 3.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TANGO6 in Genome Data Viewer
    Location:
    16q22.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (68843531..69085182)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (74639794..74881499)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (68877434..69119085)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:68778919-68779504 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:68780069 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:68787439-68788396 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:68790502 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11025 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:68791231 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11026 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:68792712 Neighboring gene RNA, 5S ribosomal pseudogene 429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11029 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:68799944 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:68800316-68800990 Neighboring gene melanoma risk locus-associated MPRA allelic enhancers 16:68802068 and 16:68802072 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:68803726 Neighboring gene Sharpr-MPRA regulatory region 4224 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:68808283 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:68813037-68813640 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:68813641-68814242 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:68814316 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:68815000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11032 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11031 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:68818245 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:68818709 Neighboring gene cadherin 1 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:68820718 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:68825333-68825902 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:68826109 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:68827591-68828091 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:68829108-68829608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:68829609-68830109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11033 Neighboring gene ferritin light chain pseudogene 14 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:68900664-68900823 Neighboring gene MPRA-validated peak2625 silencer Neighboring gene RNA, U7 small nuclear 42 pseudogene Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:69006410-69006910 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:69011625-69012125 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:69022345-69022846 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:69022847-69023346 Neighboring gene RNA, U6 small nuclear 898, pseudogene Neighboring gene deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11034 Neighboring gene ribosomal protein S2 pseudogene 45 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:69096798-69097616 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:69105561-69106280 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:69106281-69106998 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69106999-69107717 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69107718-69108435 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69111819-69112338 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69122977-69123854 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69131715-69132540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:69133965-69134466 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:69139221-69139769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7651 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69143266-69144235 Neighboring gene hyaluronan synthase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7652 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7653 Neighboring gene chromosome transmission fidelity factor 8 Neighboring gene DERPC proline and glycine rich nuclear protein Neighboring gene UTP4 small subunit processome component

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ12688, KIAA1746

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    transport and Golgi organization protein 6 homolog
    Names
    transmembrane and coiled-coil domain-containing protein 7
    transmembrane and coiled-coil domains 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024562.2NP_078838.1  transport and Golgi organization protein 6 homolog

      See identical proteins and their annotated locations for NP_078838.1

      Status: VALIDATED

      Source sequence(s)
      AB051533, AC009082, AK095333, BQ005531
      Consensus CDS
      CCDS45516.1
      UniProtKB/Swiss-Prot
      Q569F9, Q9C0B7, Q9H9K1
      UniProtKB/TrEMBL
      B3KTB6
      Related
      ENSP00000261778.1, ENST00000261778.2
      Conserved Domains (3) summary
      sd00044
      Location:838867
      HEAT; HEAT repeat [structural motif]
      pfam10304
      Location:10411073
      RTP1_C2; Required for nuclear transport of RNA pol II C-terminus 2
      pfam10363
      Location:842949
      RTP1_C1; Required for nuclear transport of RNA pol II C-terminus 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      68843531..69085182
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434632.1XP_047290588.1  transport and Golgi organization protein 6 homolog isoform X1

    2. XM_011523327.4XP_011521629.1  transport and Golgi organization protein 6 homolog isoform X2

      Conserved Domains (1) summary
      pfam10363
      Location:841901
      RTP1_C1; Required for nuclear transport of RNA pol II C-terminus 1
    3. XM_047434633.1XP_047290589.1  transport and Golgi organization protein 6 homolog isoform X3

    4. XM_047434634.1XP_047290590.1  transport and Golgi organization protein 6 homolog isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      74639794..74881499
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054313925.1XP_054169900.1  transport and Golgi organization protein 6 homolog isoform X1

    2. XM_054313926.1XP_054169901.1  transport and Golgi organization protein 6 homolog isoform X2

    3. XM_054313927.1XP_054169902.1  transport and Golgi organization protein 6 homolog isoform X3

    4. XM_054313928.1XP_054169903.1  transport and Golgi organization protein 6 homolog isoform X3