TOM20 Tom20p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TOM20
Official Full Name: Tom20p
Primary source: SGD:S000003314
Locus tag: YGR082W
See related: AllianceGenome:SGD:S000003314; FungiDB:YGR082W; VEuPathDB:YGR082W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: MAS20; MOM19
Summary: Enables mitochondrion targeting sequence binding activity. Contributes to protein transmembrane transporter activity. Involved in protein import into mitochondrial matrix and tRNA import into mitochondrion. Is integral component of mitochondrial outer membrane. Part of mitochondrial outer membrane translocase complex. Orthologous to human TOMM20 (translocase of outer mitochondrial membrane 20) and TOMM20L (translocase of outer mitochondrial membrane 20 like). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See TOM20 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (644044..644595)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TOM20-mediated transfer of Bcl2 from ER to MAM and mitochondria upon induction of apoptosis.
Title: TOM20-mediated transfer of Bcl2 from ER to MAM and mitochondria upon induction of apoptosis.
Determinism and contingencies shaped the evolution of mitochondrial protein import.
Title: Determinism and contingencies shaped the evolution of mitochondrial protein import.
Pex3p was targeted to mitochondria by fusion with the mitochondrial targeting signal of Tom20p.
Title: De novo synthesis of peroxisomes upon mitochondrial targeting of Pex3p.
Tom20 has a dual role in protein import into mitochondria: recognition of the targeting signal in the presequence and tethering the presequence to the TOM40 complex to increase import efficiency.
Title: Dual role of the receptor Tom20 in specificity and efficiency of protein import into mitochondria.
Our data reveal a large-scale mRNA association mode that involves interaction of Tom20p with the translated mitochondrial targeting sequence and may be assisted by Puf3p.
Title: Tom20 mediates localization of mRNAs to mitochondria in a translation-dependent manner.
Data Show that Tom20 are anchored in the outer membrane by a single transmembrane alpha-helix, located at the N terminus of Tom20 (signal-anchored) and that Mim1 is required for efficient membrane insertion and assembly of Tom20.
Title: Biogenesis of the mitochondrial TOM complex: Mim1 promotes insertion and assembly of signal-anchored receptors.
Tom20 and Tom22 are apparently involved in the same step or sequential steps along the same pathway of targeting signal recognition in import
Title: Tom20 and Tom22 share the common signal recognition pathway in mitochondrial protein import.
These data show that the homo-oligomerization of Mim1 allows it to fulfil its function in promoting the integration of Tom20 into the mitochondrial outer membrane.
Title: Mim1 functions in an oligomeric form to facilitate the integration of Tom20 into the mitochondrial outer membrane.
Study shows that the transmembrane segment of Tom20 contains critical residues essential for docking the Tom20 receptor into its correct environment within the TOM complex; the docking reaction is catalyzed by the unique assembly factor Mim1/Tom13.
Title: The transmembrane segment of Tom20 is recognized by Mim1 for docking to the mitochondrial TOM complex.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables mitochondrion targeting sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables mitochondrion targeting sequence binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to protein transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to protein transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein import into mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into mitochondrial matrix	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in tRNA import into mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA import into mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial outer membrane	HDA more info	PubMed
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
part_of mitochondrial outer membrane translocase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial outer membrane translocase complex	IDA Inferred from Direct Assay more info	PubMed
part_of mitochondrial outer membrane translocase complex	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Tom20p

NP_011596.1

Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

644044..644595

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181211.1 → NP_011596.1 TPA: Tom20p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011596.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUL4, P35180

UniProtKB/TrEMBL

A6ZV64, B3LIE4, B5VJ26, C7GXR1, C8Z8X6, G2WEG6, N1P9V8

Conserved Domains (1) summary

TIGR00985
Location:1 → 154

3a0801s04tom; mitochondrial import receptor subunit translocase of outer membrane 20 kDa subunit