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    HMRA2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850458, updated on 11-Sep-2024

    Summary

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    Official Symbol
    HMRA2
    Primary source
    SGD:S000000692
    Locus tag
    YCR096C
    See related
    AllianceGenome:SGD:S000000692; FungiDB:YCR096C; VEuPathDB:YCR096C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    A2
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (293179..293538, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Oca4p Neighboring gene uncharacterized protein Neighboring gene Hmra1p Neighboring gene tRNA-Thr

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Diversity of Y region at HML locus in a Saccharomyces cerevisiae strain isolated from a Sardinian wine. Pirino G, et al. Antonie Van Leeuwenhoek, 2004 Jan. PMID 15031661
    2. Regulation of yeast mating-type interconversion: feedback control of HO gene expression by the mating-type locus. Jensen R, et al. Proc Natl Acad Sci U S A, 1983 May. PMID 6344075, Free PMC Article
    3. The Action of Homothallism Genes in Saccharomyces Diploids during Vegetative Growth and the Equivalence of hma and HMalpha Loci Functions. Klar AJ, et al. Genetics, 1977 Mar. PMID 17248737, Free PMC Article
    4. On the Mechanism of Gene Silencing in Saccharomyces cerevisiae. Steakley DL, et al. G3 (Bethesda), 2015 Jun 16. PMID 26082137, Free PMC Article
    5. The sequence of the DNAs coding for the mating-type loci of Saccharomyces cerevisiae. Astell CR, et al. Cell, 1981 Nov. PMID 7034964

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    homeodomain mating type protein a2
    NP_010020.1
    • Silenced copy of a2 at HMR; similarity to Alpha2p; required along with a1p for inhibiting expression of the HO endonuclease in a/alpha HO/HO diploid cells with an active mating-type interconversion system

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      293179..293538 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178802.1 → NP_010020.1  TPA: homeodomain mating type protein a2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010020.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR97, P0CY12, P0CY13, Q6B184
      UniProtKB/TrEMBL
      A6ZTC7, B3LUE9, B5VF26, C8Z4I3, G2WAA5, N1P852
      Conserved Domains (1) summary
      smart00389
      Location:44 → 97
      HOX; Homeodomain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CY13.1

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