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    ART5 Art5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852960, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ART5
    Official Full Name
    Art5p
    Primary source
    SGD:S000003300
    Locus tag
    YGR068C
    See related
    AllianceGenome:SGD:S000003300; FungiDB:YGR068C; VEuPathDB:YGR068C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ubiquitin protein ligase binding activity. Predicted to be involved in ubiquitin-dependent endocytosis. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ART5 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (625324..627084, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Gid10p Neighboring gene uncharacterized protein Neighboring gene Rho family guanine nucleotide exchange factor ROM1 Neighboring gene Env11p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of yeast Art5 as a multicopy suppressor for the mitochondrial translocator maintenance protein Tam41. Harada Y, et al. Biochem Biophys Res Commun, 2010 Feb 5. PMID 20074554
    2. Deconstructing the genetic basis of spent sulphite liquor tolerance using deep sequencing of genome-shuffled yeast. Pinel D, et al. Biotechnol Biofuels, 2015. PMID 25866561, Free PMC Article
    3. Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria. Tamura Y, et al. Cell Metab, 2013 May 7. PMID 23623749, Free PMC Article
    4. Rsp5-dependent endocytosis and degradation of the arsenite transporter Acr3 requires its N-terminal acidic tail as an endocytic sorting signal and arrestin-related ubiquitin-ligase adaptors. Wawrzycka D, et al. Biochim Biophys Acta Biomembr, 2019 May 1. PMID 30776335
    5. Functional dissection of a HECT ubiquitin E3 ligase. Lu JY, et al. Mol Cell Proteomics, 2008 Jan. PMID 17951556, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent endocytosis ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Art5p
    NP_011582.1
    • Protein proposed to regulate endocytosis of plasma membrane proteins; regulates by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane; SWAT-GFP and mCherry fusion proteins localize to the cytosol

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      625324..627084 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181197.1 → NP_011582.1  TPA: Art5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011582.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUK2, P53244
      UniProtKB/TrEMBL
      A6ZV52, C8Z8W2, N1P5S5
      Conserved Domains (1) summary
      pfam02752
      Location:332 → 475
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53244.1

    Gene LinkOut

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